Results 31 to 40 of about 9,093,191 (259)

Performance of New Liu-type Logistic Estimators in Combating Multicollinearity [PDF]

, 2022
Multicollinearity problem in logistic regression causes an inflation in the variance of the Maximum Likelihood (ML) estimator. To overcome this serious problem, some biased estimators such as: ridge estimator, Liu estimator and Liu-type estimator, were ...
N. Yussef, Samah, H. Youssef, Ahmed, Latif S. H., Abdel   +2 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

An Investigation into Properties of Jackknifed and Bootstrapped Liu-type Estimator [PDF]

, 2018
In 2003, Liu proposed a new estimator dealing with the problem of multicollinearity in linear regression model pointing out a drawback of ridge estimator used in this context. This new estimator, called Liu-type estimator was demonstrated to have lesser
Khurana, Mansi, Chaubey, Yogendra P., Chaubey, Yogendra P, Chandra, Shalini, Chandra, Shalini Chandra   +4 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Two Classes of Almost Unbiased Type Principal Component Estimators in Linear Regression Model

Journal of Applied Mathematics, 2014
This paper is concerned with the parameter estimator in linear regression model. To overcome the multicollinearity problem, two new classes of estimators called the almost unbiased ridge-type principal component estimator (AURPCE) and the almost unbiased
Yalian Li, Hu Yang
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A New Biased Estimation Class to Combat the Multicollinearity in Regression Models: Modified Two--Parameter Liu Estimator

Computational Journal of Mathematical and Statistical Sciences
The multicollinearity problem occurrence of the explanatory variables affects the least-squares (LS) estimator seriously in the regression models. The multicollinearity adverse effects on the LS estimation are also investigated by many authors.
Mohamed Reda Abonazel
doaj   +1 more source

Robust Liu-Type Estimator for SUR Model

Statistics, Optimization & Information Computing, 2021
The Liu-type estimator is one of the shrink estimators that is used to remedy for a problem of multicollinearityin SUR model, but it is sensitive to the outlier. In this paper, we introduce the S Liu-type (SLiu-type) and MM Liu-type estimator (MMLiu-type) for SUR model.
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source