Results 41 to 50 of about 123,927 (253)

Two Classes of Almost Unbiased Type Principal Component Estimators in Linear Regression Model

Journal of Applied Mathematics, 2014
This paper is concerned with the parameter estimator in linear regression model. To overcome the multicollinearity problem, two new classes of estimators called the almost unbiased ridge-type principal component estimator (AURPCE) and the almost unbiased
Yalian Li, Hu Yang
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

High Dimensional Semiparametric Gaussian Copula Graphical Models

, 2012
In this paper, we propose a semiparametric approach, named nonparanormal skeptic, for efficiently and robustly estimating high dimensional undirected graphical models.
Han, Fang, Lafferty, John, Liu, Han, Wasserman, Larry, Yuan, Ming   +4 more
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Enhancing Poisson-inverse Gaussian ridge-type estimation for overdispersed and multicollinear data: Properties, estimation techniques, and application [PDF]

AIP Advances
The Poisson inverse Gaussian regression model (PIGRM) is widely used for modeling overdispersion in count data, outperforming baseline Poisson and negative binomial regression models, particularly when dealing with longer tails and higher kurtosis data ...
Fatimah M. Alghamdi, Ali T. Hammad, Gizachew Tirite Gellow, Gamal A. Abd-Elmougod, Ahmed M. Gemeay, Eslam Hussam   +5 more
doaj   +1 more source

Shifted Liu-Type Estimator in The Linear Regression

Jurnal Matematika, Statistika dan Komputasi, 2022
The methods to solve the problem of multicollinearity have an important issue in the linear regression. The Liu-type estimator is one of these methods used to reduce its effect. This estimator is an estimator with two parameters denoted  and . Kurnaz and Akay (2015) [6] introduced a new approach for the Liu-type estimator and called it new Liu-type (NL)
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A New Biased Estimation Class to Combat the Multicollinearity in Regression Models: Modified Two--Parameter Liu Estimator

Computational Journal of Mathematical and Statistical Sciences
The multicollinearity problem occurrence of the explanatory variables affects the least-squares (LS) estimator seriously in the regression models. The multicollinearity adverse effects on the LS estimation are also investigated by many authors.
Mohamed Reda Abonazel
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source