Results 211 to 220 of about 107,308 (356)

CocoVax: a web server for codon-based deoptimization of viral genes in live attenuated vaccine design. [PDF]

Nucleic Acids Res
Li J, Shuai S.
europepmc   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

Engineering a recombination-resistant live attenuated vaccine candidate with suppressed interferon antagonists for PEDV. [PDF]

J Virol
Liu M, Aryal B, Niu X, Wang Q.
europepmc   +1 more source

The Matrix Gene Segment Destabilizes the Acid and Thermal Stability of the Hemagglutinin of Pandemic Live Attenuated Influenza Virus Vaccines [PDF]

, 2014
Christopher D. O’Donnell, Leatrice Vogel, Yumiko Matsuoka, Hong Jin, Kanta Subbarao   +4 more
openalex   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Cost Effectiveness of Recombinant Zoster Vaccine and Live-Attenuated Vaccine Against Herpes Zoster for Adults Aged 50 and Over in China. [PDF]

Pharmacoecon Open
Liu L, Zhang Q, Shu Y, Wang L, Shuai Z, Chu M, Zhang Z, Zhang R.   +7 more
europepmc   +1 more source

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. [PDF]

PLoS Pathog, 2023
Sharp CP, Thompson BH, Nash TJ, Diebold O, Pinto RM, Thorley L, Lin YT, Sives S, Wise H, Clohisey Hendry S, Grey F, Vervelde L, Simmonds P, Digard P, Gaunt ER.   +14 more
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine. [PDF]

J Virol
Bai Y-Z, Xu H, Liu Y-G, Sun Y, Xu S-J, Wang M-X, Wang Q, Tian Z-J, Leng C-L, Wang G, An T-Q, Cai X-H, Zhang H-L, Tang Y-D.   +13 more
europepmc   +1 more source

Recent Developments in Mycobacteria-Based Live Attenuated Vaccine Candidates for Tuberculosis. [PDF]

Biomedicines, 2022
Flores-Valdez MA, Kupz A, Subbian S.
europepmc   +1 more source