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Live, Attenuated Mumps-Virus Vaccine
New England Journal of Medicine, 1968Abstract Jeryl-Lynn strain (B level) live, attenuated mumps-virus vaccine was administered to 6283 initially susceptible children and 163 adults, including 132 males. There was no evident clinical reaction to the vaccine either in adults or in children including infants.
M R, Hilleman +3 more
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Live Attenuated Vaccine Vectors
International Journal of Technology Assessment in Health Care, 1994AbstractSeveral different live attenuated vaccine vectors currently are under development. These vaccines are composed of living viruses or bacteria that are innocuous to the host but can replicate in host tissues and induce immune responses. The genes encoding foreign antigens can be inserted into these vectors to produce multivalent vaccines that ...
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Influenza Vaccination with a Live Attenuated Vaccine
AJN, American Journal of Nursing, 2009Influenza is a highly contagious, acute respiratory illness with a long history of outbreaks dating back several centuries. Although immunization is an effective means of protection against influenza, vaccination rates have been suboptimal, especially among certain high-risk groups, including children and health care personnel.
Michele, Michael +4 more
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Live Attenuated Influenza Vaccine - A review
Journal of preventive medicine and hygiene, 2011Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered ?sub-optimal?. Many studies have been carried out in recent years to improve vaccines.
GASPARINI, ROBERTO +3 more
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Live Attenuated Oral Poliovirus Vaccine
Clinical Infectious Diseases, 1984During 1952-1954, some of the first papers were published on the attenuation of wild poliovirus for vaccine purposes. These efforts soon came to fruition , and large-scale field trials were held in many countries under a variety of conditions. Routine use of live oral poliovirus vaccines ( OPV ) was begun in many countries during the spring of 1960 ...
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Live-attenuated chikungunya virus vaccine
CellAlthough Chikungunya fever does not a have a high fatality rate (
Lisa F P, Ng, Laurent, Rénia
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Live Attenuated Varicella-Zoster Vaccine
Clinical Infectious Diseases, 1980Varicella-zoster (VZ) virus causes two diseases, varicella and zoster. Because it was recognized that, after varicella, latent VZ virus persisted in the host and because varicella was thought to be a milde disease, there was little impetus in North America to develop a live VZ vaccine.
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Live Attenuated Viral Vaccines
2014The history of vaccination using live viruses extends through several centuries and is directly intertwined with the elimination of smallpox (variola major, Plotkin and Plotkin 2004). The word vaccine comes from the Latin “vaccinus” meaning “of cows”—an adjective joining variola (smallpox) and vaccinae to form cowpox (variola vaccinae, Jenner 1798 ...
Mark S. Galinski +3 more
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Vaccination with Live Attenuated Measles Virus
Archives of Pediatrics & Adolescent Medicine, 1962Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
R B, HORNICK +2 more
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Immunization with Live Attenuated Poliovirus Vaccine
Archives of Pediatrics & Adolescent Medicine, 1961Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of ...
S, KRUGMAN +5 more
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