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Live Attenuated Influenza Vaccine in Children

Seminars in Pediatric Infectious Diseases, 2006
Live attenuated influenza vaccine (LAIV) offers a novel approach to influenza vaccination and is approved for healthy individuals 5 to 49 years of age. In placebo-controlled studies in children, LAIV was 73 to 93 percent efficacious, and protection lasted more than 12 months.
Christopher S, Ambrose   +2 more
openaire   +2 more sources

Live attenuated vaccines for human use

Current Opinion in Biotechnology, 1992
Live attenuated vaccines have been successfully used for the prevention of a number of viral and bacterial diseases. Several vaccine strains have been utilized recently as expression vectors for cloned heterologous antigens. Through the use of recombinant DNA technology, candidate vaccine strains and vector systems have been developed and are ...
openaire   +2 more sources

A live attenuated human rotavirus vaccine

Drugs of Today, 2007
Rotavirus infections are the leading cause of severe gastroenteritis in young children worldwide. This review provides a summary of the development of a live oral rotavirus vaccine, Rotarix (GlaxoSmithKline, Rixensart, Belgium) developed from a single protective G1P[8] human strain.
openaire   +2 more sources

Live Attenuated Human Rotavirus Vaccine, Rotarix™

Seminars in Pediatric Infectious Diseases, 2006
Rotavirus infections are the leading cause of severe gastroenteritis in young children worldwide. Recently two new rotavirus vaccines have entered the world market. This review provides a summary of the rationale, development, and evaluation of one of these vaccines, Rotarix.
openaire   +2 more sources

Live Attenuated Vaccines for Pandemic Influenza

2009
In this chapter, we will review the development of and clinical experience with the currently licensed seasonal live attenuated influenza vaccines (LAIV) and preclinical studies of H5, H7, and H9 live attenuated pandemic influenza vaccine candidates. Vectored vaccine approaches will not be reviewed in this chapter.
Grace L, Chen, Kanta, Subbarao
openaire   +2 more sources

Designing spatial and temporal control of vaccine responses

Nature Reviews Materials, 2021
Shih Hao Ou, Wei Luo, Bali Pulendran
exaly  

COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials

Nature Reviews Clinical Oncology, 2021
Aakash Desai   +2 more
exaly  

[Influenza live attenuated vaccine].

Nihon rinsho. Japanese journal of clinical medicine, 2001
Inactivated influenza vaccine has been widely used; however, its effectiveness is not always perfect. To create a much better vaccine, live vaccines have been extensively investigated. Among several candidate live vaccines, cold-adapted(Ca) vaccine is the only promising candidate. According to clinical studies recently conducted in the U.S., Ca vaccine
openaire   +1 more source

Emerging concepts in the science of vaccine adjuvants

Nature Reviews Drug Discovery, 2021
Bali Pulendran, Prabhu S Arunachalam
exaly  

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