Results 61 to 70 of about 41,266 (261)

Developing live vaccines against plague

Journal of Infection in Developing Countries, 2011
Three great plague pandemics caused by the gram-negative bacterium Yersinia pestis have killed nearly 200 million people and it has been linked to biowarfare in the past. Plague is endemic in many parts of the world.
Wei Sun, Kenneth L Roland, Roy Curtiss III   +2 more
doaj   +1 more source

One-way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential [PDF]

, 2014
We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human-to-human transmission is not easily overcome once the virus has crossed from wild birds to chickens.
Alexander, Baigent, Banks, Banks, Belser, Blumenkrantz, Bosch, Brass, Bullough, Butt, Castrucci, Cauldwell, Chan, Chen, Chen, Cheng, Chutinimitkul, Cohen, Connor, Costa, Cotter, Cowling, Cox, De Jong, Dorigatti, DuBois, Elderfield, England, Everitt, Gabbard, Galloway, Gambaryan, Gambaryan, Gao, Garten, Handel, Harvey, Hatta, Hay, Herfst, Hoffmann, Imai, Jia, Karron, Keleta, Killingley, Koerner, Koopmans, Krenn, Kuchipudi, Li, Li, Lin, Lin, Linster, Luke, Maines, Matrosovich, Matrosovich, Matrosovich, Matrosovich, Matsuoka, Munier, Neumann, O'Donnell, Pappas, Peiris, Perdue, Reed, Roberts, Robinson, Roche, Rogers, Rott, Russell, Russell, Schrauwen, Shelton, Shi, Skehel, Smeenk, Sorrell, Sorrell, Steinhauer, Stevens, Suguitan, Sun, Tellier, Tharakaraman, Thoennes, Tumpey, Vines, Wan, Wang, Washington, Webster, Wei, Xiong, Yen, Zhang, Zhou, Zhou   +101 more
core   +2 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Bacterial vaccines in poultry

Bulletin of the National Research Centre, 2020
Background Poultry bacterial pathogens are mainly controlled by using high-cost sanitary measures and medical treatment. However, the drug-resistant strains of pathogens continuously emerge, and medical treatments are often ineffective.
Nagwa S. Rabie, Zeinab M. S. Amin Girh
doaj   +1 more source

Coinfection in the host can result in functional complementation between live vaccines and virulent virus

Virulence, 2022
One of the greatest achievements of the last century is the development of vaccines against viral diseases. Vaccines are essential for battling infectious diseases and many different formulations are available, including live attenuated vaccines. However,
Huai Xu, Andrea L. Krieter, Nagendraprabhu Ponnuraj, Yvette (Yung-Tien) Tien, Taejoong Kim, Keith W. Jarosinski   +5 more
doaj   +1 more source

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines

Vaccines, 2022
Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with diarrhoea in children
Prisca Benedicto-Matambo, Julie E. Bines, Chikondi Malamba-Banda, Isaac T. Shawa, Kayla Barnes, Arox W. Kamng’ona, Daniel Hungerford, Kondwani C. Jambo, Miren Iturriza-Gomara, Nigel A. Cunliffe, Katie L. Flanagan, Khuzwayo C. Jere   +11 more
doaj   +1 more source