Results 51 to 60 of about 1,530,452 (285)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines

Frontiers in Veterinary Science, 2021
The success of inactivated and live-attenuated vaccines has enhanced livestock productivity, promoted food security, and attenuated the morbidity and mortality of several human, animal, and zoonotic diseases.
Virginia Aida, Virginia Aida, Vasilis C. Pliasas, Vasilis C. Pliasas, Peter J. Neasham, Peter J. Neasham, J. Fletcher North, J. Fletcher North, Kirklin L. McWhorter, Kirklin L. McWhorter, Sheniqua R. Glover, Sheniqua R. Glover, Constantinos S. Kyriakis, Constantinos S. Kyriakis, Constantinos S. Kyriakis   +14 more
doaj   +1 more source

Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines

, 2008
Influenza A viruses are a public-health concern as they cause annual epidemics and may initiate a pandemic. Common inactivated influenza A vaccines induce a serum antibody response, which may not be protective against virus variation in the field.
Stech, Jürgen
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Assessment of mycoplasma vaccine efficacy in reducing infection with Newcastle disease virus

VacciMonitor, 2023
The present work recorded the impact of using Mycoplasma gallisepticum vaccines on post-vaccinal response and protection against challenge with Newcastle disease virus. Specific pathogen-free chickens were divided into eight groups of forty chickens each.
Hala Mahmoud, Marwa Fathy Elsayed, Reem A. Soliman, Mounir El Safty, Moustafa A. Zaghloul   +4 more
doaj  

Coinfection in the host can result in functional complementation between live vaccines and virulent virus

Virulence, 2022
One of the greatest achievements of the last century is the development of vaccines against viral diseases. Vaccines are essential for battling infectious diseases and many different formulations are available, including live attenuated vaccines. However,
Huai Xu, Andrea L. Krieter, Nagendraprabhu Ponnuraj, Yvette (Yung-Tien) Tien, Taejoong Kim, Keith W. Jarosinski   +5 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Brucellosis: The case for live, attenuated vaccines [PDF]

Vaccine, 2009
The successful control of animal brucellosis and associated reduction in human exposure has limited the development of human brucellosis vaccines. However, the potential use of Brucella in bioterrorism or biowarfare suggests that direct intervention strategies are warranted.
Thomas A, Ficht, Melissa M, Kahl-McDonagh, Angela M, Arenas-Gamboa, Allison C, Rice-Ficht   +3 more
openaire   +2 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Live attenuated intranasal influenza vaccine [PDF]

Human Vaccines & Immunotherapeutics, 2012
Annual vaccination is the most effective means of preventing and controlling influenza epidemics, and the traditional trivalent inactivated vaccine (TIV) is by far the most widely used. Unfortunately, it has a number of limitations, the most important of which is its poor immunogenicity in younger children and the elderly, the populations at greatest ...
Esposito, Susanna Maria Roberta, V. Montinaro, E. Groppali, R. Tenconi, M. Semino, N. Principi   +5 more
openaire   +7 more sources