Results 1 to 10 of about 131,394 (205)

Cost-Effectiveness Analysis of Herpes Zoster Vaccination in a Chinese Population: Recombinant Subunit Vaccine versus Live Attenuated Vaccine [PDF]

Vaccines
Background: Currently, the recombinant subunit vaccine and live attenuated vaccine in the prevention of herpes zoster are approved for marketing in China.
Jiaqi Wang, Pengfei Jin, Hui Jin, Qiang Wang, Fengcai Zhu, Jingxin Li   +5 more
doaj   +3 more sources

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

Nature Communications, 2022
A live-attenuated COVID vaccine could enrich the current vaccine portfolio. Here, Liu et al. engineer a live-attenuated SARS-CoV-2 vaccine candidate by deleting four viral accessory genes and show immunogenicity and protection in mice and hamsters.
Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou, Antonio E. Muruato, Sivakumar Periasamy, Chaitanya Kurhade, Jessica A. Plante, Nathen E. Bopp, Birte Kalveram, Alexander Bukreyev, Ping Ren, Tian Wang, Vineet D. Menachery, Kenneth S. Plante, Xuping Xie, Scott C. Weaver, Pei-Yong Shi   +18 more
doaj   +2 more sources

Progress on innate immune evasion and live attenuated vaccine of pseudorabies virus. [PDF]

Front Microbiol, 2023
Pseudorabies virus (PRV) is a highly infectious disease that can infect most mammals, with pigs as the only natural host, has caused considerable economic losses to the pig husbandry of the world.
Nie Z, Zhu S, Wu L, Sun R, Shu J, He Y, Feng H.   +6 more
europepmc   +2 more sources

Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs. [PDF]

Emerg Microbes Infect, 2023
African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically ...
Liu Y, Xie Z, Li Y, Song Y, Di D, Liu J, Gong L, Chen Z, Wu J, Ye Z, Liu J, Yu W, Lv L, Zhong Q, Tian C, Song Q, Wang H, Chen H.   +17 more
europepmc   +2 more sources

Live Attenuated Influenza Vaccine

Current Topics in Microbiology and Immunology, 2014
Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIV) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of ...
Hong, Jin, Kanta, Subbarao
openaire   +3 more sources

From classical approaches to new developments in genetic engineering of live attenuated vaccine against cutaneous leishmaniasis: potential and immunization [PDF]

Frontiers in Public Health
Despite the development of a vaccine against cutaneous leishmaniasis in preclinical and clinical studies, we still do not have a safe and effective vaccine for human use.
Zahra Rooholamini, Hassan Dianat-Moghadam, Hassan Dianat-Moghadam, Mahsa Esmaeilifallah, Mahsa Esmaeilifallah, Hossein Khanahmad   +5 more
doaj   +2 more sources

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

Nature Microbiology, 2023
Comparison of mucosal and systemic immunity after vaccination with the live-attenuated vaccine sCPD9, mRNA vaccine BNT162b2 or an adenovirus-vectored vaccine following SARS-CoV-2 challenge in hamsters. Vaccines play a critical role in combating the COVID-
G. Nouailles, J. Adler, P. Pennitz, Stefan Peidli, L. T. Teixeira Alves, Morris Baumgardt, J. Bushe, A. Voss, A. Langenhagen, Christine Langner, Ricardo Martin Vidal, F. Pott, J. Kazmierski, Aileen Ebenig, Mona V. Lange, M. D. Mühlebach, Cengiz Goekeri, S. Simmons, Na Xing, Azza Abdelgawad, S. Herwig, G. Cichon, Daniela Niemeyer, C. Drosten, C. Goffinet, M. Landthaler, N. Blüthgen, Haibo Wu, M. Witzenrath, A. Gruber, Samantha D. Praktiknjo, N. Osterrieder, E. Wyler, Dusan Kunec, Jakob Trimpert   +34 more
semanticscholar   +1 more source

Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L

Viruses, 2022
African swine fever (ASF) is the cause of a recent pandemic that is posing a threat to much of the world swine production. The etiological agent, ASF virus (ASFV), infects domestic and wild swine, producing a variety of clinical presentations depending ...
Xuan Hanh Tran, Le Thi Thu Phuong, Nguyen Quang Huy, Do Thanh Thuy, Van Dung Nguyen, Pham Hào Quang, Quách Võ Ngôn, Ayushi Rai, Cyril G. Gay, Douglas Paul Gladue, Manuel Victor Borca   +10 more
doaj   +1 more source

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

Journal of Experimental Medicine, 2021
Yellow fever virus live attenuated vaccine can rarely cause life-threatening disease. Inherited IFNAR1 deficiency was previously reported in one patient.
P. Bastard, E. Michailidis, Hans-Heinrich Hoffmann, Marwa Chbihi, Tom Le Voyer, J. Rosain, Q. Philippot, Y. Seeleuthner, A. Gervais, M. Materna, Patricia Mouta Nunes de Oliveira, M. D. L. Maia, Ana Paula Dinis Ano Bom, Tamiris Azamor, Deborah Araújo da Conceição, E. Goudouris, A. Homma, G. Slesak, J. Schäfer, B. Pulendran, Joseph D. Miller, Ralph Huits, Rui Yang, Lindsey B. Rosen, Lucy Bizien, Lazaro Lorenzo, M. Chrabieh, Lucia V. Erazo, F. Rozenberg, M. Jeljeli, V. Béziat, S. Holland, A. Cobat, L. Notarangelo, H. Su, R. Ahmed, A. Puel, Shen-Ying Zhang, L. Abel, S. Seligman, Qian Zhang, M. MacDonald, E. Jouanguy, C. Rice, J. Casanova   +44 more
semanticscholar   +1 more source

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Cellular & Molecular Immunology, 2022
Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA, adenoviral vector and inactivated vaccines fail to induce.
Z. Ye, C. Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, R. Zhou, Peng Luo, Yun Cheng, V. Gray, Pui Wang, Hin Chu, J. Chan, K. To, Honglin Chen, Zhiwei Chen, K. Yuen, G. Ling, Shuofeng Yuan, D. Jin   +18 more
semanticscholar   +1 more source