Results 31 to 40 of about 131,394 (205)

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

open access: yesNature Medicine, 2017
Chao Shan   +13 more
semanticscholar   +3 more sources

A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs

open access: yesScience China Life Sciences, 2020
African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required.
Wei-ye Chen   +15 more
semanticscholar   +1 more source

Current Approaches to Develop a Live Vaccine against Leishmania majo

open access: yesNovelty in Biomedicine, 2017
Leishmaniasis is an infectious disease that is endemic in 88 countries. Most of the patients after recovery from the infection develop a long-lived natural immunity against re-infection.
Farshid Yeganeh   +1 more
doaj   +1 more source

Manufacture of a Stable Lyophilized Formulation of the Live Attenuated Pertussis Vaccine BPZE1

open access: yesVaccines, 2020
Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis, whereas natural infection protects against both.
Marcel Thalen   +7 more
doaj   +1 more source

Investigation of Potency and Safety of Live-Attenuated Peste des Petits Ruminant Virus Vaccine in Goats by Detection of Cellular and Humoral Immune Response

open access: yesViruses, 2023
The peste des petits ruminant (PPR) virus is a transboundary virus found in small domestic ruminants that causes high morbidity and mortality in naive herds.
Milovan Milovanović   +3 more
doaj   +1 more source

Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine

open access: yesVaccines, 2022
Solid dose vaccine formulation and delivery systems offer potential advantages over traditional liquid vaccine formulations. In addition to enhanced thermostability, needle-free delivery of unit solid dose injectable (USDI) vaccines offers safe, rapid ...
Ellie Hayhurst   +12 more
doaj   +1 more source

Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance This work demonstrates the feasibility of rationally designing and synthesizing vaccine candidates for testing in response to an emerging disease in real world conditions.
Ying Wang   +13 more
semanticscholar   +1 more source

Live Attenuated Varicella Vaccine

open access: yesThe Journal of Pediatrics, 1984
Live attenuated varicella vaccine will in all probability soon be licensed in the United States for immunization of healthy children and adults and certain immunocompromised children. This vaccine can be expected to protect susceptibles from varicella (or to modify it) in those subsequently exposed to the wild virus.
openaire   +7 more sources

MicroRNA-Attenuated Virus Vaccines

open access: yesNon-Coding RNA, 2018
Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of
Elizabeth J. Fay, Ryan A. Langlois
doaj   +1 more source

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

open access: yesmBio, 2020
Lassa virus (LASV) infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever (LF) cases. Licensed LF vaccines are not available, and anti-LF therapy is limited to off-label use of the nucleoside analog ribavirin with
Yíngyún Caì   +16 more
semanticscholar   +1 more source

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