Results 11 to 20 of about 83,645 (265)

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines

Viruses, 2019
Influenza viruses cause annual, seasonal infection across the globe. Vaccination represents the most effective strategy to prevent such infections and/or to reduce viral disease.
Laura Rodriguez, Pilar Blanco-Lobo, Emma C. Reilly, Tatsuya Maehigashi, Aitor Nogales, Andrew Smith, David J. Topham, Stephen Dewhurst, Baek Kim, Luis Martínez-Sobrido   +9 more
doaj   +1 more source

Nanopore sequencing approach for variation detection of a live attenuated Newcastle disease virus vaccine

BioTechniques, 2022
Live attenuated Newcastle disease virus (NDV) vaccines have been used widely to protect chickens against Newcastle disease. However, the vaccine issues caused by genome mutations can seriously affect poultry health. In this study, the authors demonstrate
Kai Sun, Chunyu Tian, Mengyu Cao, Xiaoping Yu, Chuanlin Yin, Zihong Ye   +5 more
doaj   +1 more source

Manufacture of a Stable Lyophilized Formulation of the Live Attenuated Pertussis Vaccine BPZE1

Vaccines, 2020
Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis, whereas natural infection protects against both.
Marcel Thalen, Anne-Sophie Debrie, Loic Coutte, Dominique Raze, Ken Solovay, Keith Rubin, Nathalie Mielcarek, Camille Locht   +7 more
doaj   +1 more source

Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated Leishmania

Microorganisms, 2023
Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still lacking a safe and effective vaccine for humans. Given this scenario, the search for a new prophylaxis alternative for controlling leishmaniasis should be a ...
Paulo O. L. Moreira, Paula M. Nogueira, Rubens L. Monte-Neto   +2 more
doaj   +1 more source

Current Approaches to Develop a Live Vaccine against Leishmania majo

Novelty in Biomedicine, 2017
Leishmaniasis is an infectious disease that is endemic in 88 countries. Most of the patients after recovery from the infection develop a long-lived natural immunity against re-infection.
Farshid Yeganeh, Mostafa Haji Molla Hoseini   +1 more
doaj   +1 more source

Investigation of Potency and Safety of Live-Attenuated Peste des Petits Ruminant Virus Vaccine in Goats by Detection of Cellular and Humoral Immune Response

Viruses, 2023
The peste des petits ruminant (PPR) virus is a transboundary virus found in small domestic ruminants that causes high morbidity and mortality in naive herds.
Milovan Milovanović, Klaas Dietze, Ulrich Wernery, Bernd Hoffmann   +3 more
doaj   +1 more source

Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine

Vaccines, 2022
Solid dose vaccine formulation and delivery systems offer potential advantages over traditional liquid vaccine formulations. In addition to enhanced thermostability, needle-free delivery of unit solid dose injectable (USDI) vaccines offers safe, rapid ...
Ellie Hayhurst, Emily Rose, Miriam Pedrera, Jane C. Edwards, Natalia Kotynska, Daisy Grainger, Yashar Sadigh, John Flannery, Ludo Bonnet, Ritwik Ritwik, Pawan Dulal, M. Keith Howard, Simon P. Graham   +12 more
doaj   +1 more source

MicroRNA-Attenuated Virus Vaccines

Non-Coding RNA, 2018
Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of
Elizabeth J. Fay, Ryan A. Langlois
doaj   +1 more source

The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine

Virology Journal, 2012
Background H5N1 highly pathogenic avian influenza virus (HPAIV) is continuously circulating in many Asian countries and threatening poultry industry and human population.
Zhang Wenting, Tu Jiagang, Zhao Zongzheng, Chen Huanchun, Jin Meilin   +4 more
doaj   +1 more source

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Nature Communications, 2022
Examples of effective live attenuated viral vaccines include the measles, mumps and rubella vaccine, as well as the chickenpox vaccine. In this work, the authors engineer a live attenuated SARS-CoV-2 virus that demonstrates attenuation in numerous in ...
Shufeng Liu, Charles B. Stauft, Prabhuanand Selvaraj, Prabha Chandrasekaran, Felice D’Agnillo, Chao-Kai Chou, Wells W. Wu, Christopher Z. Lien, Clement A. Meseda, Cyntia L. Pedro, Matthew F. Starost, Jerry P. Weir, Tony T. Wang   +12 more
doaj   +1 more source