Results 11 to 20 of about 131,394 (205)

Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

Cell Host and Microbe, 2020
Summary The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread.
Ming-Te Yeh, E. Bujáki, Patrick T. Dolan, Matthew M. Smith, R. Wahid, John O. Konz, A. Weiner, A. Bandyopadhyay, P. van Damme, I. De Coster, H. Revets, A. Macadam, R. Andino   +12 more
semanticscholar   +3 more sources

Generation of a live attenuated influenza A vaccine by proteolysis targeting

Nature Biotechnology, 2022
L. Si, Quan Shen, Jing Li, Li Chen, Jinying Shen, Xue Xiao, H. Bai, Tang Feng, A. Y. Ye, Lewyn Li, Chunhe Zhang, Zhuguo Li, Ping Wang, Crystal Oh, Atiq Nurani, S. Niu, Chengxin Zhang, Xiaoqiong Wei, W. Yuan, H. Liao, Xiao-jie Huang, Ning Wang, W. Tian, H. Tian, Li Li, Xiaoheng Liu, R. Plebani   +26 more
semanticscholar   +3 more sources

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Nature, 2020
Lorena Sanchez-Felipe, T. Vercruysse, Sapna Sharma, Ji Ma, V. Lemmens, Dominique Van Looveren, Mahadesh Prasad Arkalagud Javarappa, R. Boudewijns, B. Malengier-Devlies, L. Liesenborghs, S. Kaptein, Carolien de Keyzer, Lindsey Bervoets, Sarah Debaveye, M. Rasulova, L. Seldeslachts, Li-Hsin Li, Sander Jansen, M. B. Yakass, B. Verstrepen, Kinga P. Böszörményi, Gwendoline Kiemenyi-Kayere, N. van Driel, O. Quaye, Xin Zhang, Sebastiaan ter Horst, N. Mishra, W. Deboutte, J. Matthijnssens, Lotte Coelmont, C. Vandermeulen, E. Heylen, V. Vergote, D. Schols, Zhongde Wang, W. Bogers, T. Kuiken, E. Verschoor, C. Cawthorne, K. Van Laere, G. Opdenakker, G. Vande Velde, B. Weynand, D. Teuwen, P. Matthys, J. Neyts, Hendrik Jan Thibaut, K. Dallmeier   +47 more
semanticscholar   +3 more sources

Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

npj Vaccines, 2021
Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus that causes the disease melioidosis. B. pseudomallei expresses a number of proteins that contribute to its intracellular survival in the mammalian host.
Sarah M. Baker, E. Settles, C. Davitt, Patrick S. Gellings, Nicole Kikendall, J. Hoffmann, Yihui Wang, J. Bitoun, Kasi-Russell Lodrigue, J. Sahl, P. Keim, C. Roy, J. McLachlan, L. Morici   +13 more
semanticscholar   +1 more source

Research progress on live attenuated vaccine against African swine fever virus.

Microbial Pathogenesis, 2021
African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya.
Le Liu, Xiangwei Wang, R. Mao, Yahua Zhou, Juanbin Yin, Yue Sun, Xiangping Yin   +6 more
semanticscholar   +1 more source

A novel fiber-2-edited live attenuated vaccine candidate against the highly pathogenic serotype 4 fowl adenovirus

Veterinary Research, 2021
Recently, the outbreaks of hydropericardium-hepatitis syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry globally.
Quan Xie, Shiya Cao, Wei Zhang, Weikang Wang, Luyuan Li, Qiuqi Kan, Hui Fu, T. Geng, Tuofan Li, Zhimin Wan, Wei Gao, H. Shao, A. Qin, Jianqiang Ye   +13 more
semanticscholar   +1 more source

H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines. [PDF]

PLoS ONE, 2009
Live attenuated influenza H5N1 vaccines have been produced and evaluated in mice and ferrets that were never exposed to influenza A virus infection (Suguitan et al., Plos Medicine, e360:1541, 2006).
Xing Cheng, Michael Eisenbraun, Qi Xu, Helen Zhou, Deepali Kulkarni, Kanta Subbarao, George Kemble, Hong Jin   +7 more
doaj   +1 more source

Rational Development of Live-Attenuated Zika Virus Vaccines

Pathogens, 2023
Zika virus (ZIKV), a re-emerging mosquito-borne flavivirus, has caused outbreaks in Africa, Asia, the Pacific, and, more recently, in the Americas. ZIKV has been associated with the neurological autoimmune disorder Guillain–Barre syndrome in adults and ...
Awadalkareem Adam, Christy Lee, Tian Wang   +2 more
doaj   +1 more source

Construction and Characterization of an Aeromonas hydrophila Multi-Gene Deletion Strain and Evaluation of Its Potential as a Live-Attenuated Vaccine in Grass Carp

Vaccines, 2021
Aeromonas hydrophila is an important pathogen that causes motile Aeromonas septicemia (MAS) in the aquaculture industry. Aerolysin, hemolysin, serine protease and enterotoxins are considered to be the major virulence factors of A. hydrophila.
Jihong Li, Shilin Ma, Zhi Li, Wei Yu, P. Zhou, Xiang Ye, M. Islam, Yong‐An Zhang, Yang Zhou, Jinquan Li   +9 more
semanticscholar   +1 more source

Safety of measles-containing vaccines in post-marketing surveillance in Anhui, China. [PDF]

PLoS ONE, 2017
The safety of measles vaccination is of great interest and importance to public health practice and the general society. We have analyzed the adverse events following immunization (AEFIs) of currently used measles-containing vaccines (including live ...
Fan-Ya Meng, Yong Sun, Yong-Gang Shen, Hai-Feng Pan, Ji-Hai Tang, Bin-Bing Wang, Chang-Hao Wu, Dong-Qing Ye   +7 more
doaj   +1 more source