Results 41 to 50 of about 131,394 (205)

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding

open access: yesCell Reports, 2021
Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and ...
J. Trimpert   +17 more
semanticscholar   +1 more source

The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine

open access: yesVirology Journal, 2012
Background H5N1 highly pathogenic avian influenza virus (HPAIV) is continuously circulating in many Asian countries and threatening poultry industry and human population.
Zhang Wenting   +4 more
doaj   +1 more source

Live Attenuated Varicella Vaccine: Prevention of Varicella and of Zoster

open access: yesJournal of Infectious Diseases, 2021
Michiaki Takahashi developed the live attenuated varicella vaccine in 1974 . This was the first, and is still the only, herpesvirus vaccine. Early studies showed promise, but the vaccine was rigorously tested on immunosuppressed patients because of their
A. Gershon, M. Gershon, E. Shapiro
semanticscholar   +1 more source

Live attenuated oral cholera vaccines

open access: yesExpert Review of Vaccines, 2006
Live, orally administered, attenuated vaccine strains of Vibrio cholerae have many theoretical advantages over killed vaccines. A single oral inoculation could result in intestinal colonization and rapid immune responses, obviating the need for repetitive dosing. Live V.
Edward T, Ryan   +2 more
openaire   +2 more sources

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

open access: yesNature Communications, 2022
Examples of effective live attenuated viral vaccines include the measles, mumps and rubella vaccine, as well as the chickenpox vaccine. In this work, the authors engineer a live attenuated SARS-CoV-2 virus that demonstrates attenuation in numerous in ...
Shufeng Liu   +12 more
doaj   +1 more source

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

open access: yesmBio, 2020
Lassa virus (LASV), the causative agent of Lassa fever, infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever cases. No U.S. Food and Drug Administration-licensed countermeasures are available to prevent or treat
Yíngyún Caì   +15 more
semanticscholar   +1 more source

Five-year antibody persistence in children after one dose of inactivated or live attenuated hepatitis A vaccine

open access: yesHuman Vaccines & Immunotherapeutics, 2017
In China, both inactivated hepatitis A (HA) vaccine and live attenuated HA vaccine are available. We conducted a trial to evaluate 5-year immune persistence induced by one dose of inactivated or live attenuated HA vaccines in children.
Zhilun Zhang   +10 more
doaj   +1 more source

Preparation Of Live Attenuated Vaccine Against Strangles

open access: yesThe Iraqi Journal of Veterinary Medicine, 2007
Live attenuated vaccine of Strept. Equi was prepared by culturing the bacterium in increasing concentration of acriflavin and the vaccine was given by installation in the nose of rabbits.
M. M. Kaisium
doaj   +1 more source

Research note: Comparison of live attenuated and non-attenuated Eimeria vaccines on safety following overdose administration using the European pharmacopoeia monograph model

open access: yesPoultry Science
Live non-attenuated and attenuated coccidiosis vaccines are available and induce a solid immune response to Eimeria spp. However, knowledge regarding the safety of live non-attenuated Eimeria vaccines is still limited.
Marc Pagès   +5 more
doaj   +1 more source

Oronasal or Intramuscular Immunization with a Thermo-Attenuated ASFV Strain Provides Full Clinical Protection against Georgia 2007/1 Challenge

open access: yesViruses, 2022
African swine fever (ASF) is a contagious viral disease of suids that induces high mortality in domestic pigs and wild boars. Given the current spread of ASF, the development of a vaccine is a priority.
Olivier Bourry   +7 more
doaj   +1 more source

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