Results 61 to 70 of about 131,394 (205)

Comparative evaluation of live attenuated and killed tachyzoites as vaccine candidates for toxoplasmosis

AMB Express
Toxoplasma gondii (T.gondii) an obligate intracellular protozoan, causes toxoplasmosis, leading to significant economic losses and posing serious public health challenges worldwide.
Eman E. El Shanawany, Eman H. Abdel-Rahman, Waleed A. Nemr, Soad E. Hassan, Noha M. F. Hassan, Hassan M. Desouky, Rabab Zalat, Amany Ebrahim Nofal, Raafat M. Shaapan, Salwa Sami Younis   +9 more
doaj   +1 more source

A live attenuated varicella vaccine

Uirusu, 2009
The vaccine virus was isolated from a vesicle of a 3-year-old otherwise healthy boy called Oka (his family name) who had typical varicella. This virus was passaged through human embryonic lung cells, guinea pig embryonic cells at a low temperature, and human diploid cells (WI-38). It was then adapted to MRC-5 human diploid cells for vaccine preparation.
openaire   +3 more sources

Evaluation of the Efficacy and Cross-Protective Immunity of Live-Attenuated Chimeric PCV1-2b Vaccine Against PCV2b and PCV2d Subtype Challenge in Pigs

Frontiers in Microbiology, 2018
Porcine circovirus type 2 (PCV2) commercial vaccines are either inactivated PCV2 isolates or subunit vaccine based on the Cap protein of PCV2. Currently, no live-attenuated vaccines are yet available.
Changchao Huan, Changchao Huan, Changchao Huan, Mingyu Fan, Mingyu Fan, Mingyu Fan, Qingru Cheng, Qingru Cheng, Qingru Cheng, Xiaobo Wang, Xiaobo Wang, Xiaobo Wang, Qingqing Gao, Qingqing Gao, Qingqing Gao, Wanbin Wang, Song Gao, Song Gao, Song Gao, Song Gao, Xiufan Liu, Xiufan Liu, Xiufan Liu   +22 more
doaj   +1 more source

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Frontiers in Immunology, 2020
Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis.
Eranga Abeyratne, Eranga Abeyratne, Kothila Tharmarajah, Kothila Tharmarajah, Joseph R. Freitas, Joseph R. Freitas, Helen Mostafavi, Helen Mostafavi, Suresh Mahalingam, Suresh Mahalingam, Ali Zaid, Ali Zaid, Mehfuz Zaman, Adam Taylor, Adam Taylor   +14 more
doaj   +1 more source

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Nature Communications, 2017
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission.
Chao Shan, Antonio E. Muruato, B. W. Jagger, Justin M. Richner, B. Nunes, D. B. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, W. Kong, T. Pierson, A. Barrett, S. Weaver, S. Rossi, P. F. Vasconcelos, B. Graham, M. Diamond, P. Shi   +17 more
semanticscholar   +1 more source

λ-Red-Recombineering Live Attenuated ΔipaD Shigella dysenteriae from Iranian Isolates as A Candidate of Vaccine [PDF]

Journal of Sciences, Islamic Republic of Iran, 2012
Shigella species (spp.) are gram-negative bacteria that are responsible for shigellosis. Although it can be controlled via antibiotics, increasing number of antibiotic resistant isolates of Shigella have been reported. Therefore, other strategies such as
M Heidari
doaj  

Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice.

PLoS ONE, 2012
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a delicate compromise between sufficient colonization-mediated adaptive immunity and minimizing the risk for infection by the vaccine strain itself.
Balamurugan Periaswamy, Lisa Maier, Vikalp Vishwakarma, Emma Slack, Marcus Kremer, Helene L Andrews-Polymenis, Michael McClelland, Andrew J Grant, Mrutyunjay Suar, Wolf-Dietrich Hardt   +9 more
doaj   +1 more source

Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice.

PLoS Neglected Tropical Diseases
Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. CHIKV is considered a priority pathogen by CEPI and WHO.
Irina Tretyakova, Joongho Joh, Mary Gearon, Jennifer Kraenzle, Sidney Goedeker, Ava Pignataro, Brian Alejandro, Igor S Lukashevich, Donghoon Chung, Peter Pushko   +9 more
doaj   +1 more source

An overview of VaxchoraTM, a live attenuated oral cholera vaccine

Human Vaccines & Immunotherapeutics, 2020
Cholera remains a public health threat among the least privileged populations and regions affected by conflicts and natural disasters. Together with Water, Sanitation and Hygiene practices, use of oral cholera vaccines (OCVs) is a key tool to prevent ...
Tarun Saluja, Vijayalaxmi V. Mogasale, Jean-Louis Excler, Jerome H. Kim, Vittal Mogasale   +4 more
doaj   +1 more source

Live-Attenuated Respiratory Syncytial Virus Vaccines [PDF]

, 2013
Live-attenuated respiratory syncytial virus (RSV) vaccines offer several advantages for immunization of infants and young children: (1) they do not cause vaccine-associated enhanced RSV disease; (2) they broadly stimulate innate, humoral, and cellular immunity, both systemically and locally in the respiratory tract; (3) they are delivered intranasally;
Ruth A, Karron, Ursula J, Buchholz, Peter L, Collins   +2 more
openaire   +2 more sources