Results 71 to 80 of about 131,394 (205)

A Novel Live Attenuated Vaccine Candidate Protects Against Heterologous Senecavirus A Challenge

Frontiers in Immunology, 2019
Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease (VD) clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Currently there are no vaccines currently available for SVA. Here we developed a recombinant SVA strain
Bishwas Sharma, M. H. Fernandes, Marcelo de Lima, Lok Raj Joshi, S. Lawson, D. Diel   +5 more
semanticscholar   +1 more source

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

Vaccine, 2019
Background There is no licensed vaccine against enterotoxigenic Escherichia coli (ETEC), a major cause of diarrhea-associated morbidity and mortality among infants and children in low-income countries and travelers.
Clayton D. Harro, A. Louis Bourgeois, D. Sack, Richard I. Walker, B. Denearing, J. Brubaker, Nicole Maier, A. Fix, L. Dally, S. Chakraborty, J. Clements, Ingelise Saunders, M. Darsley   +12 more
semanticscholar   +1 more source

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

mBio, 2019
Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response.
Pui Wang, Min Zheng, Siu-Ying Lau, Pin Chen, Bobo Wing-Yee Mok, Siwen Liu, Honglian Liu, Xiaofeng Huang, Conor J. Cremin, Wenjun Song, Yixin Chen, Yik-Chun Wong, Haode Huang, Kelvin Kai-Wong To, Zhiwei Chen, Ningshao Xia, Kwok-Yung Yuen, Honglin Chen   +17 more
doaj   +1 more source

Progress Toward Development of Effective and Safe African Swine Fever Virus Vaccines

Frontiers in Veterinary Science, 2020
African swine fever is a major concern due to its negative impact on pork production in affected regions. Due to lack of treatment and a safe vaccine, it has been extremely difficult to control this devastating disease.
Huldah Sang, Gabrielle Miller, Shehnaz Lokhandwala, Neha Sangewar, Suryakant D. Waghela, Richard P. Bishop, Waithaka Mwangi   +6 more
doaj   +1 more source

Development of a novel equine influenza virus live-attenuated vaccine

Virology, 2018
H3N8 equine influenza virus (EIV) is an important and significant respiratory pathogen of horses. EIV is enzootic in Europe and North America, mainly due to the suboptimal efficacy of current vaccines. We describe, for the first time, the generation of a
Laura Rodríguez, S. Reedy, A. Nogales, P. Murcia, T. Chambers, L. Martínez-Sobrido   +5 more
semanticscholar   +1 more source

A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand

Human Vaccines & Immunotherapeutics, 2019
Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity.
Punnee Pitisuttithum, Ponthip Wirachwong
doaj   +1 more source

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Nature Communications, 2019
Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity.
Wouter A. A. de Steenhuijsen Piters, S. Jochems, E. Mitsi, J. Rylance, S. Pojar, E. Nikolaou, E. German, M. Holloway, Beatriz F. Carniel, M. Chu, K. Arp, E. Sanders, D. Ferreira, D. Bogaert   +13 more
semanticscholar   +1 more source

Live Attenuated Cold-Adapted Influenza Vaccines [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
Live attenuated, cold-adapted influenza vaccines exhibit several desirable characteristics, including the induction of systemic, mucosal, and cell-mediated immunity resulting in breadth of protection, ease of administration, and yield. Seasonal live attenuated influenza vaccines (LAIVs) were developed in the United States and Russia and have been used ...
openaire   +2 more sources

Attenuation of the influenza virus by microRNA response element in vivo and protective efficacy against 2009 pandemic H1N1 virus in mice

International Journal of Infectious Diseases, 2015
Background: The 2009 influenza pandemics underscored the need for effective vaccines to block the spread of influenza virus infection. Most live attenuated vaccines utilize cold-adapted, temperature-sensitive virus.
Chunlai Feng, Mingming Tan, Wenkui Sun, Yi Shi, Zheng Xing   +4 more
doaj   +1 more source

Review of long term immunogenicity and tolerability of live hepatitis A vaccine

Human Vaccines & Immunotherapeutics, 2020
Hepatitis A represents one of the major public health problems worldwide including India. Vaccination is the most effective way to prevent hepatitis A infection.
Nitin Shah, MMA Faridi, Monjori Mitra, Ashish Bavdekar, Archana Karadkhele, Gaurav Puppalwar, Rishi Jain   +6 more
doaj   +1 more source