Results 51 to 60 of about 131,394 (205)

Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses

Viruses
Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses.
Peter Pushko, Igor S. Lukashevich, Dylan M. Johnson, Irina Tretyakova   +3 more
doaj   +1 more source

Live-attenuatedShigellavaccines

Expert Review of Vaccines, 2006
Several live-attenuated Shigella vaccines, with well-defined mutations in specific genes, have shown great promise in eliciting significant immune responses when given orally to volunteers. These responses have been measured by evaluating antibody-secreting cells, serum antibody levels and fecal immunoglobulin A to bacterial lipopolysaccharide and to ...
Malabi M, Venkatesan, Ryan T, Ranallo
openaire   +2 more sources

Live attenuated vaccines against pertussis

Expert Review of Vaccines, 2014
The intensive use of pertussis vaccines has dramatically reduced the incidence of whooping cough during the 20th century. However, recent outbreaks in countries with high vaccination coverage illustrate the shortcomings of current vaccination regimens, and immunity induced by the most recent, acellular vaccines wanes much faster than anticipated. As an
Camille, Locht, Nathalie, Mielcarek
openaire   +2 more sources

Vaccination coverage and its determinants of live attenuated hepatitis A vaccine among children aged 24–59 months in 20 rural counties of 10 provinces of China in 2016

Human Vaccines & Immunotherapeutics, 2020
Objective To understand one single dose coverage of live attenuated hepatitis A vaccine and its determinants among children aged 24–59 months in 20 rural counties of 10 provinces of China in 2016.
Xiaoli Liu, Chenlu Yang, Xueqi Qu, Nan Li, Xiaona Huang, Yuning Yang, Yiming Zhao, Yan Wang, Hong Zhou   +8 more
doaj   +1 more source

Reduced immunogenicity of a live Salmonella enterica serovar Typhimurium vaccine in aged mice

Frontiers in Immunology, 2023
IntroductionNon-typhoidal Salmonella (NTS) is responsible for a high burden of foodborne infections and deaths worldwide. In the United States, NTS infections are the leading cause of hospitalizations and deaths due to foodborne illnesses, and older ...
Jessica C. Allen, Jessica C. Allen, Franklin R. Toapanta, Franklin R. Toapanta, Scott M. Baliban, Scott M. Baliban, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein, Sharon M. Tennant, Sharon M. Tennant   +10 more
doaj   +1 more source

Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging viral pathogen discovered in 2009. The virus is present in countries of East Asia and is transmitted through the bite of an infected Haemaphysalis longicornis tick ...
Kwang-Min Yu, Su-Jin Park, Min-Ah Yu, Young-Il Kim, Younho Choi, Jae U. Jung, B. Brennan, Y. Choi   +7 more
semanticscholar   +1 more source

Burkholderia pseudomallei ΔtonB Δhcp1 Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection

Msphere, 2019
In recent years, an increasing number of melioidosis cases have been reported in several regions where melioidosis is endemic and in areas where melioidosis had not commonly been diagnosed. Currently, the estimated burden of disease is around 165,000 new
N. Khakhum, P. Bharaj, Julia N. Myers, Daniel Tapia, Paul B. Kilgore, B. Ross, D. Walker, J. Endsley, A. Torres   +8 more
semanticscholar   +1 more source

Effectiveness of Live-Attenuated Genotype III Japanese Encephalitis Viral Vaccine against Circulating Genotype I Viruses in Swine

Viruses, 2022
Expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has resulted in the replacement of the dominant genotype III (GIII) viruses, raising serious public health concerns for using GIII virus-derived vaccines to effectively control JEV ...
Yi-Chin Fan, Yi-Ying Chen, Jo-Mei Chen, Chienjin Huang, Mei Huang, Shyan-Song Chiou   +5 more
doaj   +1 more source

Live attenuated pre-erythrocytic malaria vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2014
Although recent control measures have significantly reduced malaria cases and deaths in many endemic areas, an effective vaccine will be essential to eradicate this parasitic disease. Malaria vaccine strategies developed to date focus on different phases of the parasite's complex life cycle in the human host and mosquito vector, and include both ...
Gladys J, Keitany, Marissa, Vignali, Ruobing, Wang   +2 more
openaire   +2 more sources

A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon

EBioMedicine, 2020
Background: Live attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust and sustained immune response as well as to confer long-term protection.
Ya-Nan Zhang, Chen Chen, Cheng-Lin Deng, Cheng-guang Zhang, Na Li, Zhen Wang, Ling Zhao, Bo Zhang   +7 more
doaj   +1 more source