Results 81 to 90 of about 131,394 (205)

Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness.

Vaccine, 2017
Since December 2015, the first dengue vaccine has been licensed in several Asian and Latin American countries for protection against disease from all four dengue virus serotypes.
O. Wichmann, K. Vannice, E. Asturias, Expedito José de Albuquerque Luna, I. Longini, A. Lopez, Peter G. Smith, H. Tissera, I. Yoon, J. Hombach   +9 more
semanticscholar   +1 more source

Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate

mBio, 2018
Glioblastoma (GBM), the deadliest type of brain tumor, is currently incurable because of its high recurrence rate after traditional treatments, including surgery to remove the main part of the tumor and radiation and chemotherapy to target residual tumor
Qi Chen, Jin Wu, Qing Ye, Feng Ma, Qian Zhu, Yan Wu, Chao Shan, Xuping Xie, Dapei Li, Xiaoyan Zhan, Chunfeng Li, Xiao-Feng Li, Xiao-pei Qin, T. Zhao, Haitao Wu, P. Shi, Jianghong Man, C. Qin   +17 more
semanticscholar   +1 more source

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Nature Communications, 2018
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine.
Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xingyao Huang, Y. Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yongqiang Deng, T. Jiang, G. Cheng, Fu-chun Zhang, A. Davidson, Yajun Song, P. Shi, C. Qin   +16 more
semanticscholar   +1 more source

Update: ACIP Recommendations for the Use of Quadrivalent Live Attenuated Influenza Vaccine (LAIV4) — United States, 2018–19 Influenza Season

MMWR. Morbidity and mortality weekly report, 2018
Intranasally administered live attenuated influenza vaccine (LAIV) was initially licensed in the United States in 2003 as a trivalent formulation (LAIV3) (FluMist, MedImmune, LLC).
L. Grohskopf, L. Sokolow, A. Fry, E. Walter, D. Jernigan   +4 more
semanticscholar   +1 more source

Attenuated African swine fever viruses and the live vaccine candidates: a comprehensive review

Microbiology Spectrum
The African swine fever virus (ASFV) is spreading worldwide and causing huge economic losses to the global pig industry. The ASFV genome is 170–193 kb in length, contains approximately 150 open reading frames, and encodes more than 200 proteins, most of ...
Jiaqi Fan, Haisheng Yu, Faming Miao, Junnan Ke, Rongliang Hu   +4 more
doaj   +1 more source

Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection

Journal of Infectious Diseases, 2017
Summary The resurgence of pertussis may originate from inefficient vaccine-mediated protection against infection by Bordetella pertussis. Here, we show that the live attenuated vaccine BPZE1 is safe in nonhuman primates and induces robust protection ...
C. Locht, James F. Papin, Sophie Lecher, A. Debrie, M. Thalen, K. Solovay, Keith Rubin, N. Mielcarek   +7 more
semanticscholar   +1 more source

Distinct Pathological Changes in Preweaning Mice Infected with Live-Attenuated Rift Valley Fever Virus Strains

Viruses
Rift Valley fever (RVF) is a mosquito-borne zoonotic viral disease endemic to Africa and the Middle East. Live-attenuated RVF vaccines have been studied for both veterinary and human use due to their strong immunogenicity and cost-effective manufacturing.
Cigdem Alkan, Eduardo Jurado-Cobena, Tetsuro Ikegami   +2 more
doaj   +1 more source

A systematic approach to the development of a safe live attenuated Zika vaccine

Nature Communications, 2018
Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow fever 17D (YF17D) live-attenuated vaccine (LAV)
Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, E. Z. Ong, H. Tan, W. Ng, Mien T. X. Nguyen, E. Gan, S. Zhang, K. W. Chan, J. Tan, O. Sessions, Menchie Manuel, J. Pompon, Camillus Chua, S. Hazirah, K. Tryggvason, S. Vasudevan, E. Ooi   +18 more
semanticscholar   +1 more source

Live-attenuatedYersinia pestisvaccines

Expert Review of Vaccines, 2013
Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is no ideal plague vaccine available for human use, but a number of licensed killed whole-cell and live-attenuated vaccines have been available in the past. Currently, there are a number of vaccines under development, including live-attenuated, DNA and subunit ...
Xiaoyi, Wang, Xuecan, Zhang, Dongsheng, Zhou, Ruifu, Yang   +3 more
openaire   +2 more sources

Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Subunit Vaccine in Adults Previously Vaccinated With a Live Attenuated Herpes Zoster Vaccine

Journal of Infectious Diseases, 2017
The adjuvanted herpes zoster subunit vaccine candidate induces strong humoral and cellular immune responses irrespective of prior vaccination with the live attenuated zoster vaccine (ZVL), and may be an attractive option to revaccinate prior ZVL ...
K. Grupping, L. Cámpora, Martine Douha, T. Heineman, N. Klein, Himal Lal, James T Peterson, Ilse Vastiau, L. Oostvogels   +8 more
semanticscholar   +1 more source