Results 61 to 70 of about 99,732 (351)

A Potent and Effective Suicidal Listeria Vaccine Platform. [PDF]

, 2019
Live-attenuated Listeria monocytogenes has shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases.
Benanti, Erin L, Brockstedt, Dirk G, Chen, Chen, Dubensky, Thomas W, Fassò, Marcella, Hanson, William G, Lauer, Peter, Lemmens, Edward E, Leong, Meredith L, Liu, Weiqun, Portnoy, Daniel A, Rae, Chris S, Skoble, Justin   +12 more
core  

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication [PDF]

, 2017
Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia.
Bouna Diop, Brian J. Willett, Dalan Bailey, Diallo, Diallo, Felix Njeumi, Michael D. Baron, Munir, Robinson, Roeder, Zahur   +10 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

EXPERIMENTAL TRIALS OF LIVE ATTENUATED AND INACTIVATED STAPHYLOCOCCUS AUREUS VACCINES IN RABBITS [PDF]

, 2006
This study was conducted as a preliminary step on the rabbits for comparative efficacy of different vaccines of Staphylococcus aureus. Typical alpha-beta Staph. aureus species from a clinically affected mastitic buffalo was isolated.
A. SHAKOOR, M. ATHAR, G. MUHAMMAD, S. U. RAHMAN1, A. A. BUTT2, I. HUSSAIN 2 AND R. AHMAD3
core  

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, EarlyView.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source

Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines

Vaccines, 2022
Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with diarrhoea in children
Prisca Benedicto-Matambo, Julie E. Bines, Chikondi Malamba-Banda, Isaac T. Shawa, Kayla Barnes, Arox W. Kamng’ona, Daniel Hungerford, Kondwani C. Jambo, Miren Iturriza-Gomara, Nigel A. Cunliffe, Katie L. Flanagan, Khuzwayo C. Jere   +11 more
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Immune Responses in Laying Hens after an Infectious Bronchitis Vaccination of Pullets: A Comparison of Two Vaccination Strategies

Vaccines, 2021
For decades, vaccinations have been used to limit infectious bronchitis (IB) in both the broiler and layer industries. Depending on the geographical area, live attenuated vaccines are used either alone or in combination with inactivated vaccines to ...
Sabrina M. Buharideen, Mohamed S. H. Hassan, Shahnas M. Najimudeen, Dongyan Niu, Markus Czub, Susantha Gomis, Mohamed Faizal Abdul-Careem   +6 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source