Results 111 to 120 of about 848,540 (287)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Componentes do peso vivo em cordeiros e borregos Polwarth e cruzas Texel x Polwarth Live weight components in Polwarth and Texel x Polwarth lambs and hoggets

Ciência Rural, 1995
O estudo teve por objetivo comparar e quantificar o peso vivo ao abate e seus componentes em cordeiros e borregos Polwarth (Ideal) com cruzas de Texel x ovelhas Polwarth. Foram sacrificados 59 cordeiros com 116 dias de idade, sendo 40 Polwarth (21 machos e 19 fêmeas) e 19 cruzas de Texel x ovelhas Polwarth (7 machos e 12 fêmeas) e 24 borregos com 450 ...
José Carlos Osório, Isidro Sierra, Carlos Sañudo, José Luiz Guerreiro, Pedro Osório Jardim   +4 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Nutrition of Recipient Cows

Turkish Journal of Agriculture: Food Science and Technology, 2014
Recipient cows are vitally important to the success of transferred cow embryos. Proper nutritional management of recipient cows is necessary to achieve the production results desired in each production phase of recipient management.
Tugay Ayaşan
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Relative development of tissues, commercial meat cuts and live weight components in Saanen goats Desenvolvimento relativo dos tecidos, cortes comerciais e dos componentes do peso vivo de cabritos Saanen

Revista Brasileira de Zootecnia, 2009
With the objective of evaluating the relative development of live weight (LW) components, commercial meat cuts and carcass tissues, 40 Saanen male kids were used. These animals were slaughtered when they reached 5.0, 12.5, 20.0, 27.5 and 35.0 kg of LW. The carcass was sectioned as follows: shoulder, neck, 1st to 5th rip, 6th to 13th rip, brisket, chump
Enrique Alejandro Yáñez, Kleber Tomás de Resende, Ângela Cristina Dias Ferreira, José Morais Pereira Filho, Ariosvaldo Nunes de Medeiros, Izabelle Auxiliadora Molina de Almeida Teixeira   +5 more
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Effects Of Poor Quality Desert Grass And Subsequent Refeeding On A High Plane Of Nutrition On Growth And Body Composition Of Sudan Desert Lambs [PDF]

Tropicultura, 1994
Forty two, 21 males and 21 females, weaned Sudan Desert lambs were divided according to sex and live weight into three equal groups (3 x 14). Each group was randomly fed ad libitum for 11 weeks on one of three diets : humra Aristida funiculata Trin ...
Mahgoub, O., Gaili, ESE.
doaj  

Avaliação das proporções dos cortes da carcaça, características da carne e avaliação dos componentes do peso vivo de cordeiros Evaluation of carcass cuttings proportion, meat characteristics and evaluation of live weight components of lambs

Revista Brasileira de Zootecnia, 2005
Objetivou-se, neste trabalho, avaliar a composição física da carcaça, as características da carne e a proporção dos não-componentes da carcaça do peso vivo de cordeiros abatidos aos 28 kg submetidos a diferentes sistemas alimentares. Dezoito cordeiros (Ile de France x Texel ) foram distribuídos aleatoriamente, com as respectivas mães, em três ...
Rafael Batista Medeiros Frescura, Cleber Cassol Pires, José Henrique Souza da Silva, Liziany Müller, Adriano Cardoso, Carlos Júnior Kippert, Diego Peres Neto, Cláudia Dutra da Silveira, Leandro Alebrante, Leonardo Thomas   +9 more
openaire   +1 more source