Results 141 to 150 of about 142,411 (300)
Mainstreaming livelihoods support: the Refugee Livelihoods Project
Forced Migration Review, 2004 In May 2003 UNHCR’s Evaluation and Policy Analysis Unit (EPAU) launched the Refugee Livelihoods Project to improve understanding of how refugees construct their livelihoods, to assess the nature and extent of UNHCR’s involvement in supporting refugee livelihoods and to facilitate wider information exchange.
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Is Rural Income Diversity Pro-Growth? Is It Pro-Poor? Evidence from Georgia [PDF]
This paper contributes to the literature on the role of on rural livelihood strategies in rural growth and poverty reduction. It distinguishes between livelihood diversity strategies that contribute to sustainable growth in household incomes, and those ...
Balcombe, Kelvin +3 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2012 The 'Sustainable Livelihood Development and Ethnic Minority Diversity in Lao Cai Province' project in Viet Nam aims to mobilise poor, ethnic minority farmers, the H'mong, Dao, and Tay in particular, into farmer groups and provide them with training and ...
Hughes, Karl
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Livlihood Diversification and Opinion Polls’ Analysis: Evidence From Tharparkar-Sindh (Pakistan) [PDF]
In this paper attempt has been made: (i) to analyse the opinion poll of Tharis about livilihood and its diversifaction, (ii) to identify the livlihood available resources and attitute of Tharis to these resources.
Mahmud, Muhammad +3 more
core