Results 41 to 50 of about 317,807 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Toward the Integrated Framework Analysis of Linkages among Agrobiodiversity, Livelihood Diversification, Ecological Systems, and Sustainability amid Global Change

Land, 2016
Scientific and policy interest in the biological diversity of agriculture (agrobiodiversity) is expanding amid global socioeconomic and environmental changes and sustainability interests. The majority of global agrobiodiversity is produced in smallholder
Karl S. Zimmerer, Steven J. Vanek
doaj   +1 more source

Systemizing a rural livelihood diversification framework for sustainable community-based agritourism: A participatory approach to ensure resilience

Frontiers in Sustainable Food Systems, 2022
IntroductionSituated approaches of rural livelihood diversification, such as community-based agritourism, can localize sustainable food systems at the regional level.
Sofia Anna Enrica Cavalleri, Sofia Anna Enrica Cavalleri, Puntita Tanwattana, Clemens M. Grünbühel, Clemens M. Grünbühel   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Wellbeing, productivity and food security effects of multiple livelihood diversifications: Insight from kaffa zone, Ethiopia

Cogent Social Sciences
Even if agriculture is the dominant livelihood base for most Ethiopians, currently the sector is facing many challenges. Hence, rural households are compelled to develop livelihood diversification strategies to cope with the increasing vulnerability ...
Kindineh Sisay
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lack of opportunities and persistent poverty:income diversification in rural Madagascar (In French) [PDF]

In Madagascar, the inequalities gap between urban and rural areas implies to draft rural specific policies. Nevertheless, the only focusing on growth might have a limited impact on persistent poverty.
Claire GONDARD-DELCROIX (GREThA-GRES)
core   +2 more sources

THE THEORETICAL APPROACH OF LIVELIHOODS DIVERSIFICATION

Redes, 2012
Este artigo apresenta a abordagem da diversificação dos meios de vida como um método de estudo das alternativas de vida no meio rural, uma ferramenta analítica que também permite acompanhar e avaliar o desempenho das políticas públicas de desenvolvimento rural.
Perondi, Miguel Angelo, Schneider, Sérgio   +1 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source