Results 81 to 90 of about 317,807 (291)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Agroforestry Practices, Livelihood Diversification, and Their Association With Wellbeing Status of the Smallholder Farmers in Sidama Region of Southern Ethiopia

International Journal of Forestry Research
Smallholder farmers practice various agroforestry systems; however, limited information exists on how these practices contribute to rural livelihoods and household wellbeing.
Biruk Jagiso Fonke, Beruk Berhanu Desalegn, Abrham Belay Mekonnen, Beyene Teklu Mellisse, Melisew Dejene, Tafese Mathewos, Bayou Bunkura   +6 more
doaj   +1 more source

The formal-informal institutional and policy nexus in livelihood diversification among smallholder farmers in developing countries: a systematic review

Frontiers in Sustainability
Livelihood diversification is widely recognized as a strategy for improving income stability, resilience, and food security among smallholder farmers in developing countries.
Moses Zakhele Sithole, Trevor Mishal Morepje, Variety Nkateko Thabane, Lethu Ineth Mgwenya, Nomzamo Sharon Msweli, Azikiwe Isaac Agholor, Oluwasogo David Olorunfemi, Funso Raphael Kutu   +7 more
doaj   +1 more source

The Influence of Market Barriers and Farm Income Risk on Non-Farm Income Diversification [PDF]

Empirical evidence shows that non-farm income diversification is associated with higher welfare among farm households. However, most studies have ignored market barriers and farm income risk in explaining income diversification behaviour.
Olale, Edward, Nazli, Hina
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Migration and non farm activities as income diversification strategies: the case of Northern Ghana [PDF]

Environmental changes affect the livelihood of the rural population. This is especially true for those households who mainly rely on farming for their subsistence.
Francesca Marchetta
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Gas extraction operations and livelihood diversification in Tanzania: Rhetoric and reality. [PDF]

Heliyon, 2023
Musoma BM, Nyanda SS, Muhanga MI, Massawe FA.   +3 more
europepmc   +1 more source

A Composite Fuzzy Indicator for Assessing Farm Household Potential for Non-farm Income Diversification [PDF]

European politicians encourage the income diversification of rural households through various measures. Although being aware of farm households’ potential for non-farm income diversification seems important for finely-targeting such policy measures, no ...
Fritzsch, Jana
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source