Results 111 to 120 of about 222,243 (315)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An analysis of poverty and aquatic resources use - focusing especially on the livelihoods of the poor - in Cambodia [PDF]

, 2000
The main objectives of this report, which is based on the current literature and key informant interviews, is to assess and analyse the nature and distribution of poverty and aquatic resources use, focusing especially on the livelihoods of the poor.

core  

Climate change, agriculture and international migration: An African youth perspective [PDF]

, 2020
Existing evidence indicates that Africa is already being affected by climate change resulting in substantial challenges for both human and natural systems.
Abebaw, Degnet, Bezu, Sosina, Demissie, Teferi, Huyer, Sophia, Kassa, Habtemariam, Mungai, Catherine, Solomon, Dawit   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Livelihoods, appropriate technologies, and their integration with urban development plans: the case of Nueva Ciudad de Belén, Loreto, Peru

Espacio y Desarrollo, 2018
The following article presents the current challenges for the sustainability of preventive resettlement projects, which are increasing in demand to the impacts of climate change in urban areas, proposing a better articulation between these and the urban ...
Belén Desmaison Estrada, Urphy Vásquez Baca, Kleber Espinoza Diaz   +2 more
doaj  

Impact of Farmers’ Livelihoods on Agricultural Carbon Emission Efficiency Under the Background of Population Urbanization: Evidence from China

Agriculture
In the context of China’s population urbanization, the quality and pattern of farmers’ livelihoods are undergoing significant changes. Reducing emissions and sequestering carbon in agriculture is a crucial pathway for China to achieve its “dual carbon ...
Ming Chang, Xiaotong Li, Fei Li, Hesen Zhao   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effectiveness and implementation of “Graduation Approach” livelihood programs with displaced populations: A systematic review

Abstract Background Humanitarian actors have widely adopted “Graduation” model programs to support social determinants of health—particularly sustainable livelihoods—among displaced populations. We conducted a systematic review to comprehensively evaluate the evidence regarding Graduation model ...
Lauren N Yan, Yuwei E Wang, Fred Mubangizi, Colton Parks, Caitlin Whittemore, Nigusu Zelelke   +5 more
openaire   +2 more sources

Goodbye to Projects? ¿ A livelihoods-grounded audit of the Sexual Health and Rights Programme (SHARP!) in Southern Africa. [PDF]

, 2003
Approaches to projects and development have undergone considerable change in the last decade with significant policy shifts on governance, gender, poverty eradication, and environmental issues.
Marumo, J., Tamasane, T.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source