Results 121 to 130 of about 222,243 (315)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transforming aquatic agricultural systems towards gender equality: a five country review [PDF]

, 2012
Aquatic agricultural systems (AAS) are systems in which the annual production dynamics of freshwater and/or coastal ecosystems contribute significantly to total household income.
Chiuta, T.M., Choudhury, A., Ferrer, A., Husken, S.M.C., Kantor, P., Kura, Y., Kusakabe, K., Madzudzo, E., Maetala, R., Naved, R., Schwarz, A., Weeratunge, N.   +11 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Chapter 5: Food Security [PDF]

The current food system (production, transport, processing, packaging, storage, retail, consumption, loss and waste) feeds the great majority of world population and supports the livelihoods of over 1 billion people.
Barioni, Luis G., Benkeblia, Noureddine, Benton, Tim G., Blanchard, Julia, Challinor, Andrew, Contreras, Erik Mencos, Diouf, Abdoul Aziz, Fanzo, Jessica, Frank, Stefan, Herrero, Mario, Khan, Amanullah, Kriewald, Steffan, Krishnapillai, Murukesan, Lanigan, Gary, Liwenga, Emma, Lopez, Daniel, Mason-D'Croz, Daniel, Mbow, Cheikh, Mencos Contreras, Erik A., Neofotis, Peter, Pant, Laxmi, Periera, Joana Portugal, Porter, John R., Pradhan, Prajal, Rivera-Ferre, Marta G., Rodrigues, Renato, Rosenzweig, Cynthia E., Ruane, Alex C., Ruane, Alexander C., Sapkota, Tek, Tubiello, Francesco N., Waha, Katharina, Xu, Yinlong   +32 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Potentials Of Raphia Hookeri Wine In Livelihood Sustenance Among Rural And Urban Populations In Nigeria

, 2014
Raphia wine is an important forest product with cultural significance besides its use as medicine and food in southern Nigeria. This work aims to evaluate the profitability of Raphia wine production and marketing in Sapele Local Government Area, Nigeria.
A. A. Aiyeloja, A.T. Oladele, O. Tumulo
openaire   +2 more sources

Securing the Livelihoods and Nutritional Needs of Fish-Dependent Communities [PDF]

, 2013
Starting in June 2012, the Rockefeller Foundation began investigating the pressing problem of the declining health of the oceans due to climate change, overfishing, pollution and habitat destruction, and the effects of this decline on poor and vulnerable
Amanda Goldberger, Laura Herman, Leigh Fiske   +2 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Government livelihood project - free influenza vaccination for the older population in China: the example of Zhejiang Province

Frontiers in Public Health
Influenza vaccination is an effective measure to prevent and control influenza, and countries worldwide consider older people a key recommended population for influenza vaccination. From 2020, Zhejiang Province has provided free influenza vaccination to anyone aged ≥70 years as part of its livelihood projects.
Xiaoxiao Wang, Xiaoxiao Wang, Wei Jiang, Zhao Yu, Weiping Jiang, Xiaowei Zhu, Zhen Wang, Jimin Sun, Jimin Sun, Hangjie Zhang, Hangjie Zhang   +10 more
openaire   +3 more sources