Results 81 to 90 of about 222,243 (315)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Climate change reflects on security of the border villages, case study: Salas Babajani border villages [PDF]

تحقیقات کاربردی علوم جغرافیایی, 2020
The purpose of the present study is to investigate the effects of climate change on the border security of Thalassa Babajani villages. The study area consists of 11 villages of Salas Babajani city with a population of over 2500 people. 333 questionnaires
morad Kaviani Rad, meysam toulabi nejad, farid rezaei   +2 more
doaj  

LANDSCAPE COMPONENTS' INFLUENCE ON THE SOURCE OF LIVELIHOOD OF THE POPULATION: THE CASE OF NARRA, PALAWAN

, 2020
Landscape components is composed of the different patterns of land, vegetation, bodies of water, man-made structures like highways. This study describes the profile, landscape components and source of livelihood of population in Narra Palawan through the use of landscape maps: maps on the water and land use, watershed, soil, road network ...
openaire   +2 more sources

Lessons From Livelihood Interventions that Increase the Resilience of Populations to Droughts in Afghanistan and Other FCAS [PDF]

, 2021
Creating and protecting more resilient rural livelihoods is seen as being key to advancing Afghanistan’s development and improving its reslience to climate change impacts, particularly drought. This rapid review draws on policy and programme information from donor and multi-lateral organisations and some academic literature to identify best practices ...
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Faith-Based Water Sanitation and Hygiene Initiatives: Effects on Pastoral Livelihood in Marsabit County, Kenya

Pan-African Journal of Health and Environmental Science, 2023
Background: In Marsabit County, pastoralists face challenges such as scarce clean water, proper hygiene, inadequate sanitation, and limited socioeconomic well-being.
Beatrice Kirujah, Petronilla Otuya, Duncan Ochieng   +2 more
doaj  

Voices from Urban Africa: The Impact of Urban Growth on Children [PDF]

, 2012
Urban poverty -- and its impact on children -- is often overlooked and misunderstood. More than half of the world's population now lives in cities. Each year the number of urban residents increases by nearly 60 million.1 By 2050, it is projected that two
Anne Stotler, Carol Miller, Jennifer Shindeldecker   +2 more
core  

Livelihood diversification and the expansion of artisanal mining in rural Tanzania: drivers and policy implications [PDF]

, 2010
This paper provides an extended analysis of livelihood diversification in rural Tanzania, with special emphasis on artisanal and small-scale mining (ASM).
African Development Bank, Barry M., Dreschler B., Foeken D., Gibbon P., Government of Tanzania, Government of Tanzania, IMF, IMF, IMF, International Labour Organization – ILO, Labonne B., LADDER, Lange S., Madulu N. F., Malima V., Mung'ong'o C., Mwaipopo R., Mwakalobo A., Mwakalobo B. S. A., Mwanfupe D., Paavola J., Republic of Tanzania, Republic of Tanzania, Sundaram-Stukel R., United Nations Economic Commission for Africa – UNECA, USAID, World Bank   +27 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Water is the vessel through which we ride the waves of changing climates

Frontiers in Water
Acting through water, climate change may affect livelihoods, societal structures, and political conflicts, hindering progress toward poverty reduction.
Karl Zimmermann, Camila Sancho, Varshaa Kumaran, Sifat Kalam   +3 more
doaj   +1 more source