Results 71 to 80 of about 332,718 (290)

Genetically Regulated Bilirubin and Risk of Non-alcoholic Fatty Liver Disease: A Mendelian Randomization Study

Frontiers in Genetics, 2018
Mildly elevated serum bilirubin levels were reported to be associated with decreased risk of non-alcoholic fatty liver disease (NAFLD). Whether this is a causal relationship remains unclear.
Lei Luo, Lei Luo, Ping An, Xinyong Jia, Xiaobian Yue, Sujun Zheng, Shuang Liu, Yu Chen, Wei An, Wei An, Cheryl A. Winkler, Zhongping Duan, Zhongping Duan, Zhongping Duan   +13 more
doaj   +1 more source

Comparative separation methods and biological characteristics of human placental and umbilical cord mesenchymal stem cells in serum-free culture conditions

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) are considered to be an effective tool for regenerative medicine with promising applications for clinical therapy. However, incongruent data has been reported partially owing to their functional heterogeneity.
Xiao Yi, Feng Chen, Fenghua Liu, Qing Peng, Yang Li, Shao Li, Jiang Du, Yi Gao, Yifeng Wang   +8 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Dynamic skeletal muscle loss and its predictive role on 90-day mortality in patients with acute-on-chronic liver failure

Frontiers in Nutrition
BackgroundLow skeletal muscle mass is an independent risk factor for increased mortality in patients with acute-on-chronic liver failure (ACLF). However, no study has evaluated the temporal changes in muscle mass during the course of ACLF.
Nan Geng, Ming Kong, Jiateng Zhang, Manman Xu, Huina Chen, Huina Chen, Wenyan Song, Yu Chen, Zhongping Duan   +8 more
doaj   +1 more source

Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice

Stem Cell Research & Therapy, 2019
Background Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important.
Yanzhen Bi, Jiannan Li, Yonghong Yang, Quanyi Wang, Quanquan Wang, Xiaobei Zhang, Guanjun Dong, Yibo Wang, Zhongping Duan, Zhenfeng Shu, Tongjun Liu, Yu Chen, Kai Zhang, Feng Hong   +13 more
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Cost Containment May Have a Price, But Is It a Crime? Analyzing the Basis for Criminalizing Managed Care Conduct [PDF]

, 2008
A recent transplant case raises an interesting question: Should a managed care organization (“MCO”) face criminal prosecution when a patient dies after the MCO’s decision to deny payment for treatment? Is providing such a legal cause of
Snyder, Courtney Lyons
core   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Does enternal nutrition affect clinical outcome? A systematic review of the randomized trials [PDF]

, 2007
Background: Both parenteral nutrition (PN) and enteral nutrition (EN) are widely advocated as adjunctive care in patients with various diseases. A systematic review of 82 randomized controlled trials (RCTs) of PN published in 2001 found little, if any ...
Avenell, Alison, Braunschweig, Carol L., Koretz, Ronald L., Lipman, Timothy O., Milne, Anne C.   +4 more
core  

Machine Learning with Abstention for Automated Liver Disease Diagnosis [PDF]

, 2017
This paper presents a novel approach for detection of liver abnormalities in an automated manner using ultrasound images. For this purpose, we have implemented a machine learning model that can not only generate labels (normal and abnormal) for a given ...
Abbasi, Wajid, Asif, Amina, Hamid, Kanza, Minhas, Fayyaz, Sabih, Durre   +4 more
core   +2 more sources