Results 71 to 80 of about 72,056 (263)

Key Events Participating in the Pathogenesis of  Alcoholic Liver Disease

Biomolecules, 2017
Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. It ranges from fatty liver to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.The most prevalent forms of ALD are alcoholic fatty liver, alcoholic ...
Fernando Magdaleno, Chuck C. Blajszczak, Natalia Nieto   +2 more
doaj   +1 more source

Characterization of lymphocyte subsets in ascitic fluid and peripheral blood of decompensated cirrhotic patients with chronic hepatitis C and alcoholic liver disease: A pivotal study

International Journal of Immunopathology and Pharmacology, 2020
Hepatitis C virus and alcoholic liver disease are major causes of chronic liver diseases worldwide. Little is known about differences between chronic hepatitis C and alcoholic liver disease in terms of lymphocytes’ sub-population.
Roberto Giulio Romanelli, Gianfranco Vitiello, Stefano Gitto, Maria Grazia Giudizi, Roberta Biagiotti, Alessia Carraresi, Francesco Vizzutti, Giacomo Laffi, Fabio Almerigogna   +8 more
doaj   +1 more source

Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis [PDF]

Cochrane Database of Systematic Reviews, 2000
Abstract: Aims/Background: Colchicine is an anti‐inflammatory and anti‐fibrotic drug. Several randomized clinical trials have addressed the question whether colchicine has any efficacy in patients with alcoholic as well as non‐alcoholic fibrosis and cirrhosis.
A, Rambaldi, C, Gluud
openaire   +5 more sources

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis

Journal of Immunology Research, 2018
Alcoholic cirrhosis is an end-stage liver disease with impaired survival and often requires liver transplantation. Recent data suggests that receptor-interacting protein kinase-3- (RIPK3-) mediated necroptosis plays an important role in alcoholic ...
Zhenzhen Zhang, Guomin Xie, Li Liang, Hui Liu, Jing Pan, Hao Cheng, Hua Wang, Aijuan Qu, Yan Wang   +8 more
doaj   +1 more source

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. [PDF]

PLoS ONE, 2015
Liver disease is the greatest cause of death related to alcohol and a major public health problem. While excessive alcohol intake results in hepatosteatosis in most individuals, this can progress in some to more severe forms of liver disease including ...
Peter J Meikle, Piyushkumar A Mundra, Gerard Wong, Khairunnessa Rahman, Kevin Huynh, Christopher K Barlow, Alastair M P Duly, Paul S Haber, John B Whitfield, Devanshi Seth   +9 more
doaj   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Management of adult patients with alcoholic liver disease: clinical guidelines of the Russian Scientific Liver Society

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
The aim of publication. To present clinical guidelines of the Russian Scientific Liver Society on diagnosis and treatment of alcoholic liver disease to general practitioners. Summary. Harmful alcohol intake is the burning issue for Russia.
V. T. Ivashkin, M. V. Mayevskaya, Ch. S. Pavlov, Yu. P. Sivolap, V. D. Lunkov, M. S. Zharkova, R. V. Maslennikov   +6 more
doaj   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source