Results 261 to 270 of about 119,037 (316)

Liver cirrhosis: An overview of experimental models in rodents

Life Sciences, 2022
The liver, a component of the gastrointestinal tract, is one of the most important organs in the human body. The liver performs over 500 functions to promote physiological homeostasis. In addition, the liver acts as a screen, by metabolizing substances carried by blood coming from the digestive tract before they enter the systemic circulation.
Lanuza A P, Faccioli, Marlon Lemos, Dias, Bruno Andrade, Paranhos, Regina Coeli, Dos Santos Goldenberg   +3 more
openaire   +2 more sources

Intrarenal Alterations in Experimental Liver Cirrhosis

Physiology, 1996
In liver cirrhosis, renal reabsorption of water and sodium precedes ascites formation. Reduced renal excretory rates can be found in the absence of changes in plasma levels of main systemic hormones. It is possible that intrarenal elevations of antinatriuretic systems participate in retention of water and sodium in early cirrhosis.
M Atucha, G-E Joaquin
openaire   +1 more source

Collagenolytic activity in experimental cirrhosis of the liver

Experimental and Molecular Pathology, 1987
Collagenolytic activity has been measured in insoluble sediments of normal and CCl4-induced cirrhotic rat liver. Two techniques were used: in one assay, the insoluble liver sediments were incubated with a radioactively labeled exogenous substrate; in the other assay, the endogenous collagen present in the insoluble liver sediments served as the ...
R, Perez-Tamayo, I, Montfort, E, Gonzalez   +2 more
openaire   +2 more sources

Dobutamine Prevents Experimental Postintoxication Liver Cirrhosis in Mice

Bulletin of Experimental Biology and Medicine, 2002
Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte proliferation ...
A P, Vinokurov, A V, Eremeev, N A, Setkov   +2 more
openaire   +2 more sources

EXPERIMENTAL CIRRHOSIS OF THE LIVER

JAMA: The Journal of the American Medical Association, 1913
Ever since Laennec 1 first described cirrhosis of the liver, there has been an immense amount of experimental work done as to the etiology and histology of this disease. Joannovics 2 in 1904 gave a summary of the work that had been done up to that time together with a summary of the methods used.
openaire   +1 more source

EXPERIMENTAL CIRRHOSIS OF THE LIVER

Journal of the American Medical Association, 1942
To the Editor:— We wish to express our appreciation for the recent editorial mention (The Journal, October 24, p. 624) of our studies on experimental cirrhosis of the liver. From this editorial, however, those who are not familiar with the study might infer that the detailed analysis of the dietary factors involved in the pathogenesis of this disease ...
openaire   +1 more source

Erythrocyte catalase in liver cirrhosis and in experimental liver injury

Experientia, 1963
Nous avons trouve que l'activite de la catalase des erythrocytes chez les cirrhotiques et chez les chiens intoxiques par CCl4 est considerablement diminuee, tandis que le numero globulaire et le taux d'hemoglobine ne representent que des changements tres peu signicatifs.
openaire   +2 more sources

Experimental Modeling of Alcohol-Induced Liver Cirrhosis in Rats

Bulletin of Experimental Biology and Medicine, 2018
An experimental model of alcohol-induced liver cirrhosis in white outbred rats was developed: intragastric administration of 40% ethanol (3 g/kg) every other day for 3 weeks and simultaneous intraperitoneal administration of 1% of N-nitrozodimethylamine (5 mg/kg) for 4 consecutive days of each week.
A E, Antushevich, A E, Antushevich, A N, Grebenyuk, D A, Khalyutin, A A, Yartseva   +4 more
openaire   +2 more sources

PATHOLOGY OF LIVER CIRRHOSIS IN EXPERIMENTAL SCHISTOSOMIASIS JAPONICA

Acta Pathologica Japonica, 1971
Rabbits were experimentally infected with Scbistosoma japonicum to observe morphological alterations of the liver to the 60th week of infection in chronological sequence. In the present report, the developing process of liver cirrhosis due to Schistosoma japonicum was elucidated together with the repairing process occurring after its cirrhotic state ...
openaire   +2 more sources

Role of Vascular Nitric Oxide in Experimental Liver Cirrhosis

Current Vascular Pharmacology, 2005
One of the most important features of liver cirrhosis is the splanchnic and systemic arterial vasodilation, related to an increase in vascular capacity and an active vasodilation. This arterial vasodilation seems to be the consequence of the excessive generation of vasodilating substances, which also contributes to a lower than normal pressor response ...
Noemí M, Atucha, F Javi A, Nadal, David, Iyú, Antonia, Alcaraz, Alicia, Rodríguez-Barbero, M Clara, Ortiz, José Miguel, López-Novoa, Joaquín, García-Estañ   +7 more
openaire   +2 more sources