Results 81 to 90 of about 73,718 (217)

Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats

BMC Veterinary Research, 2010
Background Domestic dogs and cats are very well known to develop chronic hepatic diseases, including hepatic lipidosis and cirrhosis. Ultrasonographic examination is extensively used to detect them.
Campos de Carvalho Antonio, Tura Bernardo R, Rezende Guilherme FM, Takiya Christina M, Quintanilha Luiz, Carvalho Adriana B, Dias Juliana V, Paredes Bruno D, Lessa Andréia S, Resende Célia MC, Goldenberg Regina CS   +10 more
doaj   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, EarlyView.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

H-Ras Oncogene Expression and Angiogenesis in Experimental Liver Cirrhosis

Gastroenterology Research and Practice, 2013
Background. Proto-oncogenes, particularly ras, may not only affect cell proliferation but also contribute to angiogenesis by influencing both proangiogenic and antiangiogenic mediators.
Gülsüm Özlem Elpek, Betül Ünal, Sevgi Bozova   +2 more
doaj   +1 more source

Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection Revisão de modelos experimentais de cirrose hepática induzida por ligadura do ducto biliar e por injeção de tetracloreto de carbono

Acta Cirúrgica Brasileira, 2012
PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
Thamirys Guimarães Marques, Eleazar Chaib, Juliana Hamati da Fonseca, Ana Cecília Rodrigues Lourenço, Felipe Duarte Silva, Marcelo Augusto Fontenelle Ribeiro Jr, Flavio Henrique Ferreira Galvão, Luiz Augusto Carneiro D'Albuquerque   +7 more
doaj   +1 more source

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

The Effect of Snakehead Fish on Superoxide Dismutase Levels and Gastric Histopathological Features in a Rat Model of Liver Cirrhosis

Jurnal Inovasi Pendidikan dan Sains
Liver cirrhosis is a chronic disease that frequently leads to complications such as portal hypertensive gastropathy (PHG), which is characterized by increased oxidative stress and reduced activity of antioxidant enzymes such as Superoxide Dismutase (SOD).
OK Yulizal, Fitorius Gaurifa, Yuliani Mardiati Lubis   +2 more
doaj   +1 more source

Effect of Resistance Exercises on Muscle Strength, Fatigue Severity and Daily Living Activities among Patients with Liver Cirrhosis [PDF]

Egyptian Journal of Health Care
Background: Decreased muscle strength, fatigue and limited in implementing activity of daily livings (ADLs) are prominent symptoms in liver cirrhosis patients.
Aml S. Abdelbaky, Eman AbdelRazik AbdelHakim, Shaimaa F. Kamel, Hend Elham Mohammed   +3 more
doaj   +1 more source