Results 41 to 50 of about 241,143 (264)

NKG2D Enhances Double-Negative T Cell Regulation of B Cells

Frontiers in Immunology, 2021
Numerous studies reported a small subpopulation of TCRαβ+CD4-CD8- (double-negative) T cells that exert regulatory functions in the peripheral lymphocyte population. However, the origin of these double-negative T (DNT) cells is controversial.
Shi-hua Hu, Long-hui Zhang, Jie Gao, Jing-heng Guo, Xiao-dong Xun, Xiao Xiang, Qian Cheng, Qian Cheng, Zhao Li, Zhao Li, Ji-ye Zhu, Ji-ye Zhu   +11 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Pyogenic liver abscess caused by trans-gastric migration of a toothpick managed with laparoscopic left lateral sectionectomy and gastric perforation repair: a case report

Frontiers in Surgery
BackgroundPyogenic liver abscess caused by migration of an ingested toothpick through occult gastrointestinal perforation is rare and may be missed.Case presentationA 47-year-old woman presented with 2 weeks of fever and epigastric pain. Laboratory tests
Zhigao Yuan, Xingfei Li, Jiye Zhu, Jie Gao   +3 more
doaj   +1 more source

Survival COVID-19 in Adult Patients with Liver Cirrhosis

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2021
Background: COVID-19 is a disease caused by infection of SARS-CoV-2 virus which leads to mortality due to respiratory failure. The progression of COVID-19 is more severe in patients with pre-existence morbidities, including liver disease. Recently, a few
Gita Aprilicia, Syahrizal Syarif, Kemal Fariz Kalista, Andri Sanityoso Sulaiman, Irsan Hasan, Cosmas Rinaldi A Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Saut Horas Hatoguan Nababan, Rino Alvani Gani   +9 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Hemostatic Abnormalities in Patient with Liver Cirrhosis: A Review

Jurnal Kedokteran Diponegoro, 2022
Liver cirrhosis is one of Indonesia’s most common liver diseases, where the incidence is 38 – 52.8% of all liver diseases. Liver cirrhosis refers to a late-stage pathological lesion caused by the accumulation of extracellular matrix in the liver ...
Wahyuni Wahyuni, Diana Novita
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

ON THE TREATMENT OF CIRRHOSIS OF THE LIVER. [PDF]

JAMA: The Journal of the American Medical Association, 1901
Cirrhosis of the liver—often called alcoholic cirrhosis —is seen under the following circumstances: 1, without symptoms, the patient having died from other causes; 2, without symptoms until a climax is reached in the sudden outbreak of gastric or intestinal hemorrhage, terminating the life of the patient; 3, with symptoms due to obstruction of the ...
openaire   +2 more sources