Results 201 to 210 of about 12,874,292 (410)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Liver Surgery in Relation to Diseases of the Colon and Rectum
, 1957 Ronald W. Raven
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The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
THE LIPIDS OF SERUM AND LIVER IN PATIENTS WITH HEPATIC DISEASES 1 [PDF]
, 1945 Evelyn B. Man +3 more
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FEBS Open Bio, EarlyView.In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li +5 more
wiley +1 more source
Lettsomian Lectures on the Pathology and Treatment of Some Diseases of the Liver [PDF]
, 1872 S. O. Habershon
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International Journal of Circumpolar HealthDirect-acting antiviral (DAA) hepatitis C treatment can reduce fibrosis and prevent cirrhosis and its sequelae. This study aims to evaluate changes in fibrosis and lab measurements from pre-treatment to post-treatment and over time following the end-of ...
Janet M. Johnston +7 more
doaj +1 more source
A STUDY OF PYRUVIC ACID IN THE BLOOD AND SPINAL FLUID OF PATIENTS WITH LIVER DISEASE WITH AND WITHOUT HEPATIC COMA 1 [PDF]
, 1950 Donald S. Amatuzio, Samuel Nesbitt
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FEBS Open Bio, EarlyView.Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto +5 more
wiley +1 more source
THE EFFECT OF BARBITURATES IN PATIENTS WITH LIVER DISEASE 1 [PDF]
, 1954 John T. Sessions +3 more
openalex +1 more source