Results 41 to 50 of about 47,063 (217)

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications

Advanced Science, EarlyView.
Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee, SeongCheol Jang, Wangmyung Choi, Jaewon Park, Jaehyun Hur, Hocheon Yoo, Hyun‐Suk Kim   +6 more
wiley   +1 more source

Non-invasive Diagnostics of Liver Fibrosis

Acta Medica Bulgarica, 2017
Detecting new units of pathogenesis in the liver fibrosis due to alcoholism, chronic viral Hepatitis B and C, non-alcoholic fatty liver disease (NAFLD), autoimmune, parasitic and metabolic diseases and other, reveals perspective for new non-invasive ...
Mihaylov R., Pencheva B., Stoeva D., Ruseva A.   +3 more
doaj   +1 more source

Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.

PLoS ONE, 2012
BackgroundSCP/TAPS proteins of parasitic helminths have been proposed to play key roles in fundamental biological processes linked to the invasion of and establishment in their mammalian host animals, such as the transition from free-living to parasitic ...
Cinzia Cantacessi, Andreas Hofmann, Neil D Young, Ursula Broder, Ross S Hall, Alex Loukas, Robin B Gasser   +6 more
doaj   +1 more source

Delaying the Inevitable? U.S. Screwworm Closures and Feeder Cattle Market Dynamics

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Biosecurity trade restrictions are commonly framed as preventive measures, yet in many settings they function primarily as policies of delay: they impose immediate market costs while only postponing the arrival of biological risks. This paper evaluates that intertemporal tradeoff using the 2024–2025 US suspension of live cattle imports from ...
Shelby Sumner, Savannah Jones, Tania Islam, K. Aleks Schaefer   +3 more
wiley   +1 more source

Protein palmitoylation in hepatic diseases: Functional insights and therapeutic strategies

Journal of Advanced Research
Background: Liver pathologies represent a spectrum of conditions ranging from fatty liver to the aggressive hepatocellular carcinoma (HCC), as well as parasitic infections, which collectively pose substantial global health challenges.
Ying Wang, Haoyuan Ma, Bowen Zhang, Sainan Li, Beijia Lu, Yingcheng Qi, Tingting Liu, Hua Wang, Xiaohong Kang, Yinming Liang, Eryan Kong, Liu Cao, Binhui Zhou   +12 more
doaj   +1 more source

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

Frontiers in Immunology
The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway has emerged as a central regulator of liver homeostasis and pathology, governing innate immunity, inflammation, fibrogenesis, and tissue repair.
Yichen Fan, Zihao Dong, Yufeng Wu, Hao Wen   +3 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Serodiagnosis of amoebic abscess: a retrospective diagnostic accuracy study of kits marketed in Europe

Journal of Clinical Microbiology
Amoebiasis is a cosmopolitan parasitic disease caused by Entamoeba histolytica. The most lethal form is extra-intestinal amoebiasis, mainly manifesting as liver abscesses. Diagnosis is based on clinical, radiological, and biological tests. However, there
E. Prétot, M-P. Brenier-Pinchart, P. Tirard-Collet, F. Gabriel, F. Touafek, A. Marteau, L. Delcey, C. Amiot, D. Dupont, H. Fricker-Hidalgo, H. Sokol, A. Moreno-Sabater, F. Grenouillet   +12 more
doaj   +1 more source

Booster immunity – diagnosis of chronic hepatitis B viral infection

Journal of Infection in Developing Countries, 2019
Introduction: Diagnosis of chronic hepatitis B virus (HBV) infection particularly its occult form requires monitoring and repeat serological and molecular studies.
Radka T Komitova, Ani K Kevorkyan, Maria V Atanasova, Aneta V Ivanova, Elica Golkocheva-Markova   +4 more
doaj   +1 more source