Results 51 to 60 of about 12,320,543 (412)
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
BMC Gastroenterology, 2023 Background Irritable bowel syndrome (IBS) is one of the world's most common gastrointestinal (GI) disorders, and current treatments do not meet patients' demands.
Masood Faghih Dinevari +5 more
doaj +1 more source
Postgraduate Medical Journal, 2000 Abstract Alcohol is a major cause of liver cirrhosis in the Western world and accounts for the majority of cases of liver cirrhosis seen in district general hospitals in the UK. The three most widely recognised forms of alcoholic liver disease are alcoholic fatty liver (steatosis), acute alcoholic hepatitis, and alcoholic cirrhosis.
K, Walsh, G, Alexander
openaire +2 more sources
Immunological mechanisms and therapeutic targets of fatty liver diseases
Cellular & Molecular Immunology, 2020 Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major types of chronic liver disease worldwide. Inflammatory processes play key roles in the pathogeneses of fatty liver diseases, and continuous inflammation promotes
Hua Wang, W. Mehal, L. Nagy, Y. Rotman
semanticscholar +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients
Military Medical Research, 2020 Background Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and ...
Qi Wang +14 more
doaj +1 more source
Melatonin inhibits bile acids-initiated Cxcl2 expression through JNK/c-Jun signalling pathway
Di-san junyi daxue xuebao, 2022 Objective To investigate the underlying molecular mechanism by which melatonin suppresses bile acids (BAs)-initiated expression of chemokine C-X-C motif chemokine ligand 2 (Cxcl2). Methods Mice were fed a 1% cholic acid (CA)-supplemented diet for 2 weeks
TAN Ya +5 more
doaj +1 more source
A note on the prothrombin time abnormality in the patients with amebic liver abscess [PDF]
, 2006 Amebic liver abscess is reported worldwide and can present with a a wide spectrum of clinical manifetations. Similar to the other liver diseases, the prothrombin time abnormality can be seen in the patients with amebic liver abscess.
Suwansaksri, Jamsai +2 more
core +1 more source
The incidence of portal vein thrombosis at liver transplantation [PDF]
, 1992 The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S +3 more
core +1 more source
The Gut-Liver Axis in Cholestatic Liver Diseases
Nutrients, 2021 The gut-liver axis describes the physiological interplay between the gut and the liver and has important implications for the maintenance of health. Disruptions of this equilibrium are an important factor in the evolution and progression of many liver ...
Andreas Blesl, V. Stadlbauer
semanticscholar +1 more source