Results 41 to 50 of about 1,230,040 (315)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Serum microRNA-122 predicts survival in patients with liver cirrhosis

, 2012
Background: Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers.
Stefan Zeuzem, Albrecht Piiper (22854), Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Verena Köberle (130993), Bernd Kronenberger (131004), Bernd Kronenberger, Verena Köberle, Waidmann, Oliver, Albrecht Piiper, Oliver Waidmann (130988), Piiper, Albrecht, Friederike Brunner (130998), Köberle, Verena, Brunner, Friederike, Zeuzem, Stefan, Stefan Zeuzem (22856)   +17 more
core   +1 more source

Safety of fibrates in cholestatic liver diseases

, 2021
Off-label use of fibrates in patients with cholestatic liver diseases results in improved biochemical parameters and pruritus; however, their safety in this population has been a concern.
Cynthia Levy, Carrion, Andres F, Levy, Cynthia, Lindor, Keith D, Keith D. Lindor, Andres F. Carrion   +5 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study

BMC Gastroenterology, 2023
Background Irritable bowel syndrome (IBS) is one of the world's most common gastrointestinal (GI) disorders, and current treatments do not meet patients' demands.
Masood Faghih Dinevari, Farzaneh Jafarzadeh, Amirreza Jabbaripour Sarmadian, Samaneh Abbasian, Zeinab Nikniaz, Ali Riazi   +5 more
doaj   +1 more source

Long-Term Outcome Following Liver Transplantation for Primary Hepatic Tumors—A Single Centre Observational Study over 40 Years

, 2023
The incidence of pediatric liver tumors in general has been rising over the last years and so is the number of children undergoing liver transplantation for this indication.
Mutschler, Frauke E., Junge, Norman; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Mutschler, Frauke E.; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Vondran, Florian W. R.; 3Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany, Baumann, Ulrich; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Pfister, Eva-Doreen, Pfister, Eva-Doreen; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Laue, Tobias; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Ohlendorf, Johanna, Richter, Nicolas; 3Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany, Ohlendorf, Johanna; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Leiskau, Christoph; 1Pediatric Gastroenterology, Department of Pediatrics and Adolescent Medicine, University Medical Centre Göttingen, Georg August University Goettingen, 37075 Goettingen, Germany, Junge, Norman, Vondran, Florian W. R., Richter, Nicolas, Leiskau, Christoph, Laue, Tobias, Baumann, Ulrich   +17 more
core   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany [PDF]

, 2012
Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany. Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July ...
T. Sauerbruch, J. Kittner, S. Manekeller, A. Paul, Anadol, Evrim, Beckebaum, Susanne, Rockstroh, Jürgen, T. Ganten, Paul, Andreas, Bickel, Markus, J. C. Kalff, Spengler, Ulrich, E. Anadol, M. Stoll, Zoufaly, Alexander, S. Beckebaum, Kittner, Jens Martin, M. Bickel, Hitzenbichler, Florian, Stoll, Matthias, Kalff, Jörg C., A. Zoufaly, Manekeller, Steffen, Ganten, Tom M., C. Berg, F. Hitzenbichler, J. K. Rockstroh, Radecke, Klaus, K. Radecke, Berg, C., U. Spengler, Sauerbruch, Tilman   +31 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells

Pharmaceutical Biology, 2020
Context Xiayuxue decoction (XYXD), a traditional Chinese medicine, is used for treating liver disease. However, the potential active constituents and mechanisms are still unclear. Objective To explore the main active fraction extracts, active ingredients
Dingqi Zhang, Lijun Zhang, Gaofeng Chen, Ying Xu, Hailin Yang, Zhun Xiao, Jiamei Chen, Yongping Mu, Hua Zhang, Wei Liu, Ping Liu   +10 more
doaj   +1 more source