Results 41 to 50 of about 865,411 (286)

Progress in mesenchymal stem cell–based therapy for acute liver failure

Stem Cell Research & Therapy, 2018
Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. Numerous treatment strategies for acute liver failure simply prevent complications and
Yong-Hong Wang, Dong-Bo Wu, Bing Chen, En-Qiang Chen, Hong Tang   +4 more
doaj   +1 more source

Acute liver injury, acute liver failure and acute on chronic liver failure: A clinical spectrum of poisoning due to Gyromitra esculenta

Annals of Hepatology, 2019
Gyromitra esculenta, also known as “false morel” is one of the most poisonous mushrooms. This species is found all over the world, growing in coniferous forest in early spring time.
Magdalena Arłukowicz-Grabowska, Maciej Wójcicki, Joanna Raszeja-Wyszomirska, Monika Szydłowska-Jakimiuk, Bernard Piotuch, Piotr Milkiewicz   +5 more
doaj   +1 more source

Plasma Glutamine Concentrations in Liver Failure. [PDF]

PLoS ONE, 2016
Higher than normal plasma glutamine concentration at admission to an intensive care unit is associated with an unfavorable outcome. Very high plasma glutamine levels are sometimes seen in both acute and chronic liver failure.
Gunnel Helling, Staffan Wahlin, Marie Smedberg, Linn Pettersson, Inga Tjäder, Åke Norberg, Olav Rooyackers, Jan Wernerman   +7 more
doaj   +1 more source

Acute-On-Chronic Liver Failure-Outcome and Its Predictors in A Tertiary Care Hospital

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the characteristics and outcome of acute-on-chronic liver failure patients being managed at PakEmirates Military Hospital Rawalpindi. Study Design: Cross-sectional study.
Rao Saad Shadab, Muhammad Shoaib Khan, Farrukh Saeed, Syed Kumail Hasan Kazmi, Fuad Ahmed Siddiqi, Rafi Ud Din   +5 more
doaj   +1 more source

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

Cell Proliferation, 2020
Acute kidney injury (AKI) is a common complication of acute liver failure (ALF). Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role of TNF‐α/HMGB1 pathway in pyroptosis during ALF and AKI.
Yao Wang, Haiyue Zhang, Qian Chen, F. Jiao, Chunxia Shi, M. Pei, Jian Lv, Hong Zhang, Luwen Wang, Zuojiong Gong   +9 more
semanticscholar   +1 more source

The Comparison of LightGBM and XGBoost Coupling Factor Analysis and Prediagnosis of Acute Liver Failure

IEEE Access, 2020
This paper focuses on the comparison of dimensionality reduction effect between LightGBM and XGBoost-FA. With respect to XGBoost, LightGBM can be built in the effect of dimensionality reduction via both Gradient-based One-Side Sampling(GOSS) and ...
Dongyang Zhang, Yicheng Gong
semanticscholar   +1 more source

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

Toxicological Sciences, 2020
Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is a significant clinical problem in most western countries. The only clinically approved antidote is N-acetylcysteine (NAC), which promotes the recovery of hepatic GSH.
H. Jaeschke, J. Akakpo, David S. Umbaugh, A. Ramachandran   +3 more
semanticscholar   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Acute Liver Failure

HPB Surgery, 1999
To consider the classification and to present an approach to the diagnosis and management of complications associated with acute liver failure.A review of studies reported from 1966 to 1998 and identified through a MEDLINE search on treatment of acute liver failure.Acute liver failure can be subdivided into hyperacute, (encephalopathy within 7 days of ...
Lee, William M., Williams, Roger
openaire   +4 more sources