Results 101 to 110 of about 2,037,125 (314)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Prediction of liver disease in patients whose liver function tests have been checked in primary care : model development and validation using population-based observational cohorts [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
Altman, Carstairs, Chambless, Collett, Craig, D'Agostino, Donnan, Donnan, Dorans, Evans, Fornasini, Goodwin, Hawkins, Kim, McLernon, McLernon, Moons, Morris, Pencina, Pratt, R Core Team, Roderick, Rubin, Rubin, Schalk, Sherwood, Siris, Sorensen, Steinke, Sterne, Steyerberg, Sullivan, Vickers, Vickers, Yuan   +34 more
core   +5 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Changes in life-style after liver transplantation [PDF]

, 1988
Sixty-five pediatric patients who received liver transplants between May 1981 and May 1984 were observed for as many as 5 years and examined for changes in life-style.
Belle, SH, Carlton Gartner, J, Kirkpatrick, B, Malatack, JJ, Miller, JW, Starzl, TE, Urbach, AH, Williams, L, Zitelli, BJ   +8 more
core  

The clinical significance of the arterial ketone body ratio as an early indicator of graft viabilityin human liver transplantation [PDF]

, 1991
Arterial ketone body ratio (AKBR) was measured sequentially in 84 liver transplantations (OLTx). These transplantation procedures were classified into 3 groups with respect to graft survival and patient condition at the end of the first month (Group A ...
Asonuma, K, Okamoto, R, Ozawa, K, Selby, R, Starzl, TE, Takaya, S, Todo, S, Yamamoto, Y, Yokoyama, T   +8 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Comparison of various lazaroid compounds for protection against ischemic liver injury [PDF]

, 1997
Lazaroids are a group of 21-aminosteroids that lack steroid action but have a potent cytoprotective effect by inhibiting iron-dependent lipid peroxidation.
Ishizaki, N, Kobayashi, Y, Lee, RG, Nemoto, A, Starzl, TE, Subbotin, VM, Todo, S, Zhang, S, Zhu, Y   +8 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pretransplant assessment of human liver grafts by plasma lecithin: cholesterol acyltransferase (LCAT) activity in multiple organ donors. [PDF]

, 1992
In spite of the improved outcome of orthotopic liver transplantation (OLTx), primary graft nonfunction remains one of the life-threatening problems following OLTx.
A Lanir, AJ Demetris, BW Shaw, E Gjone, Hidefumi Higashi, J Fath, J Gugenheim, JB Simon, K Takenaka, K Yanaga, Katsuhiko Yanaga, KL Svensson, L Makowka, Leonard Makowka, M Kalayoglu, M Oellerich, M Shimada, Mitsuo Shimada, R Jenkins, S Todo, Saburo Kakizoe, T Nagasaki, TE Starzl, Thomas E. Starzl, W Kamiike, Y Taki   +25 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source