Results 111 to 120 of about 2,073,621 (363)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Anti-inflammatory Effects of Phyllanthus amarus Extracts Against Benzene-Induced Leukemia in Rats [PDF]

Avicenna Journal of Medical Biochemistry
Background: The present study examined the protective effects of extracts from Phyllanthus amarus on benzene-induced leukemia in Wistar rats. Benzene is a carcinogen linked to increased leukemia risk.
Arinze Favour Anyiam, Musa Abidemi Muhibi, Godfrey Innocent Iyare, Pius Omoruyi Omosigho , Matthew Folaranmi Olaniyan, Ejeatuluchukwu Obi, Onyinye Cecilia Arinze-Anyiam, Fagbile Oluwafemi Emmanuel, Oyinloye Omotayo Rachel, Emmanuel Ifeanyi Obeagu, Ukpai Eze   +10 more
doaj   +1 more source

Hyaluronate levels in donor organ washout effluents: a simple and predictive parameter of graft viability [PDF]

, 1996
The principal cause of primary non-function in orthotopic liver transplantation is thought to be preservation injury to the microvasculature. We, therefore, evaluated if effluent levels of hyaluronate, whose uptake is an endothelial cell marker, could ...
Adams, Bramley, Campbell, Clavien, D'Alessandro, Deaciuc, Deaciuc, Deaciuc, Deaciuc, Deaciuc, Delong, Engstrom-Laurent, Eriksson, Fraser, Frebourg, Furukawa, Greig, Gressner, Ikeda, Kakizoe, Karyalcin, Makowka, McKeown, Morgan, Nyberg, Otto, Paulsen, Plebani, Pollard, Prehm, Rosner, Shaw, Smedsrod, Starzl, Todo   +34 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Liver transplant modulates gut microbial dysbiosis and cognitive function in cirrhosis [PDF]

, 2017
Jasmohan S. Bajaj, Andrew Fagan, Masoumeh Sikaroodi, Melanie B. White, Richard K. Sterling, HoChong Gilles, Douglas M. Heuman, Richard T. Stravitz, Scott Matherly, M. Shadab Siddiqui, Prem Puri, Arun J. Sanyal, Velimir A. Luketic, Binu V. John, Michael Fuchs, Vishwadeep Ahluwalia, Patrick M. Gillevet   +16 more
openalex   +1 more source

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Progressive Hypoxia-on-a-chip: An In Vitro Oxygen Gradient Model for Capturing the Effects of Hypoxia on Primary Hepatocytes in Health and Disease

, 2019
Oxygen is vital to the function of all tissues including the liver and lack of oxygen, that is, hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo.
Bulutoglu, Beyza, Eo, Jinsu, Kang, Young Bok Abraham, Usta, O. Berk, Yarmush, Martin L.   +4 more
core   +1 more source

Liver transplantation for type I and type IV glycogen storage disease [PDF]

, 1993
Progressive liver failure or hepatic complications of the primary disease led to orthotopic liver transplantation in eight children with glycogen storage disease over a 9-year period.
A. G. Tzakis, AS Guerra, B Illingworth, B. I. Brown, BI Brown, BI Brown, BI Brown, CA Alper, D Raum, DA Merrill, E. Yunis, GA Bannayan, GB Reed, GM Greene, GT Cori, H Zellweger, HG Hers, HL Greene, IT Ferguson, JJ Malatack, JJ Siekierka, KR McMaster, MW Harding, N Kashiwagi, N Kashiwagi, R. S. Kendall, R. Selby, RC Nordlie, S Servidei, S. Todo, T Ishihara, T. E. Starzl, TE Starl, TE Starzl, TE Starzl, TE Starzl, TE Starzl, V Mazzaferro   +37 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source