Results 41 to 50 of about 12,928,896 (364)

Synthesis, conformational control, and photothermal application of helically twisted 3,6-carbazole-based porphyrinoids and mono-palladium complex

Nature Communications
Synthetic control over multiple conformations of expanded porphyrinoids, which are intrinsically linked to their properties and functions, has long been a key objective in chemical research.
Chengming Li, Weihua Zhuang, Yongjie Zhou, Linfeng He, Jiayin Yang, Gang Xu, Rongchuan Su, Mao Chen, Jingsong You   +8 more
doaj   +1 more source

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Scientific Reports, 2016
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness ...
Catherine C. Bell, D. Hendriks, Sabrina M. L. Moro, Ewa C. S. Ellis, Joanne Walsh, A. Renblom, Lisa Fredriksson Puigvert, A. Dankers, F. Jacobs, J. Snoeys, R. Sison-Young, R. Jenkins, Å. Nordling, S. Mkrtchian, B. K. Park, N. Kitteringham, C. Goldring, V. M. Lauschke, M. Ingelman-Sundberg   +18 more
semanticscholar   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction

Biomedicines, 2023
Hepatic dysfunction is commonly observed in subjects with hyperthyroidism. Hepassocin is a hepatokine playing an important role in metabolic diseases and exhibiting a hepatic protective effect.
Chih-Chen Wang, Ching-Han Lin, Hsuan-Wen Chou, Chung-Teng Wang, Yu-Cheng Liang, Hung-Tsung Wu, Horng-Yih Ou   +6 more
doaj   +1 more source

The association of liver function and quality of life of patients with liver cancer

BMC Gastroenterology, 2019
BackgroundQuality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall survival (OS) in patients with ...
Leung Li, F. Mo, E. Hui, S. Chan, J. Koh, N. Tang, Simon Yu, W. Yeo   +7 more
semanticscholar   +1 more source

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Gut, 2022
Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.
J. Rao, Hao Wang, Ming Ni, Zeng Wang, Ziyi Wang, Song Wei, Mu Liu, Peng Wang, Jiannan Qiu, Lei Zhang, Chen Wu, Hongbing Shen, Xuehao Wang, F. Cheng, Ling Lu   +14 more
semanticscholar   +1 more source

Between Droughts and Floods: The Seasonal Response of Freshwater Snails in Artificial Reservoirs in the Brazilian Semiarid Region

Population Ecology, EarlyView.
We investigate the seasonal dynamics of two freshwater snails, Biomphalaria straminea and Melanoides tuberculata, in artificial reservoirs of the Brazilian semiarid region. Despite regulated hydrology, B. straminea exhibited strong seasonal fluctuations associated with dry periods, while M. tuberculata maintained stable populations throughout the year,
Lucas Henrique Sousa da Silva, João Hemerson de Sousa, Adriana Josefa da Rocha, Manuella Feitosa Leal, Lucas Ariel de Sousa Aguiar, Tamaris Gimenez Pinheiro, Edson Lourenço da Silva   +6 more
wiley   +1 more source

Effectiveness and Safety of Remdesivir for the Treatment of COVID-19 Patients with Liver Cirrhosis: A Retrospective Cohort Study

Life
Background: Patients with liver cirrhosis are at an increased risk of mortality from coronavirus disease 2019 (COVID-19). Remdesivir, an adenosine analog, exhibits activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is thus ...
Yi-Ching Wong, Chip-Jin Ng, Yan-Bo Huang, Shou-Yen Chen   +3 more
doaj   +1 more source

Hepatotoxicity Caused by Repeated and Subchronic Pulmonary Exposure to Low-Level Vinyl Chloride in Mice

Atmosphere, 2021
Vinyl chloride (VC) is classified as a group 1 carcinogen to humans by the International Agency for Research on Cancer, and inhalation is considered to be an important route of occupational exposure.
Li-Te Chang, Yueh-Lun Lee, Tzu-Hsuen Yuan, Jer-Hwa Chang, Ta-Yuan Chang, Chii-Hong Lee, Kin-Fai Ho, Hsiao-Chi Chuang   +7 more
doaj   +1 more source

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

Scientific Reports, 2018
Ursodeoxycholic acid (UDCA) is a metabolic by-product of intestinal bacteria, showing hepatoprotective effects. However, its underlying molecular mechanisms remain unclear.
D. Kim, Seonghae Yoon, S. Ji, Jinho Yang, Yoon-Keun Kim, SeungHwan Lee, K. Yu, I. Jang, J. Chung, Joo-Youn Cho   +9 more
semanticscholar   +1 more source