Results 91 to 100 of about 965,195 (303)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Dynamic dual regulation of amphiregulin in liver pathophysiology: balancing regeneration and disease progression via the EGFR axis

Frontiers in Medicine
Liver diseases, ranging from acute injury to chronic fibrosis and hepatocellular carcinoma (HCC), represent a major global health challenge with limited therapeutic options.
Yi-Li Wang, Yi-Li Wang, De-Jiang Zhou, Qiong-Wan Wang, Qiong-Wan Wang, Ye Zhang, Ye Zhang, Wen-Jing Yang, Wen-Jing Yang, Wen-Jie Tan, Wen-Jie Tan, Hao-Yu Wang, Hao-Yu Wang, Xiao-Wan Chen, Xiao-Wan Chen, San-Qiang Li, San-Qiang Li   +16 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway. [PDF]

, 2015
Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC).
Geng, Wei, Li, Chang-Xian, Ling, Chang-Chun, Liu, Xiao-Bing, Lo, Chung-Mau, Ma, Yuen-Yuen, Man, Kwan, Ng, Kevin TP, Qi, Xiang, Zhai, Yuan   +9 more
core   +1 more source

Оценка состояния протяженных выработок с длительным сроком службы шахт Центрального Донбасса на примере Шахтоуправления «Покровское» [PDF]

, 2011
Chemokines critically control the infiltration of immune cells upon liver injury, thereby promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect trafficking of monocytes/macrophages, monocyte-derived dendritic cells (DCs) and
Bartneck, Matthias, Gaßler, Nikolaus, Hammerich, Linda, Heymann, Felix, Huss, Sebastian, Lira, Sergio A., Lüdde, Tom, Rüsseler, Vanessa, Storch, Dunja, Tacke, Frank, Trautwein, Christian   +10 more
core   +1 more source

Turmeric-Induced Liver Injury

Journal of Community Hospital Internal Medicine Perspectives
The use of herbal and dietary supplements has gained an increasing foothold in the United States. While often touted as safer alternatives to more traditional "western" therapeutics, the pharmacology and pharmacokinetics of these substances, their interactions with other medications, their purity, and individual pharmacogenomics, remain unknown ...
Alghzawi, Fadi, Jones, Robert, Haas, Christopher J.   +2 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

CD47, a novel YAP target gene, contributes to hepatic stellate cell activation and liver fibrosis induced by high-fat diet

Heliyon
Activated hepatic stellate cells (HSCs) have been widely recognized as a primary source of pathological myofibroblasts, leading to the accumulation of extracellular matrix and liver fibrosis. CD47, a transmembrane glycoprotein expressed on the surface of
Ya Li, Lin Dong, Xuecui Yin, Xiaohan Wang, Xiaohui Zhu, Pengyuan Zheng, Youcai Tang   +6 more
doaj   +1 more source

SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells [PDF]

, 2017
SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been
Albano, Emanuele, Biasiolo, Alessandra, Bocca, Claudia, Busletta, Chiara, Cannito, Stefania, David, Ezio, Miglietta, Antonella, Morello, Elisabetta, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Plebani, Mario, Pontisso, Patrizia, Quarta, Santina, Sutti, Salvatore, Turato, Cristian, Villano, Gianmarco   +16 more
core   +3 more sources