Results 81 to 90 of about 965,195 (303)

Relationship between Obstructive Sleep Apnea and Liver Abnormalities in Older Patients: A Cross-Sectional Study

International Journal of Clinical Practice, 2023
Background. Older age is a risk factor for obstructive sleep apnea (OSA), which is associated with the development of nonalcoholic fatty liver disease (NAFLD).
Yong-Xu Jin, Bi-ying Wang, Xiao-li Wang, Xing Yu, Li-da Chen, Yi-song Yang, Jie-feng Huang   +6 more
doaj   +1 more source

Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]

, 2019
High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul, Khambu, Bilon, Yan, Shengmin, Yin, Xiao-Ming   +3 more
core   +1 more source

The liver injuries

Acta chirurgica Iugoslavica, 2010
The liver is the most commonly injured abdominal organ. Severe hepatic trauma continue to be associated with high mortality. Management of liver injuries has changed significantly over the last two decades. Nonoperative management of hemodynamically stable patients has become the first treatment of choice.
Aleksandar Karamarkovic, Kristina Doklestic, Vladimir Djukic, Branislav Stefanovic, Dejan Radenkovic, Pavle Gregoric, Nenad Ivancevic, Zeljko Lausevic, Nada Popovic, Djordje Bajec   +9 more
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Dissecting antibody-mediated natural killer cell effects reveals a cytotoxic CX3CR1KLRC2CD16 subset linked to hepatitis B virus outcomes [PDF]

Clinical and Molecular Hepatology
Background/Aims Natural killer (NK) cell function is generally considered dampened in chronic hepatitis B virus (HBV) infection; however, the NK cell pool exhibits phenotypic and functional heterogeneity, and the antibody-mediated effect of NK cells ...
Libo Tang, Yuhao Wang, Zihan Jin, Yurong Gu, Zhaofeng Zeng, Linnan Song, Xuan Yi, Lingtao Zhang, Yujing Zhang, Weiying He, Liping Wang, Weixin He, Jianru Sun, Xiaoqin Lan, Xiangyong Li, Shihong Zhong, Yongyin Li   +16 more
doaj   +1 more source

The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]

, 1989
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F., Bannister P., Bardin C. W., Booth A. N., Cardon S. B., Chamness G. C., D. H. Van Thiel, D. Kahn, Eagon P. K., Eisenfeld A. J., Farrell G. C., Francavilla A., Francavilla A., Gustafsson J. A., H. Lai, Higgins E. M., L. Makowka, Lowry O. H., M. Kajani, P. K. Eagon, Q. Zeng, Starzl T. E., T. E. Starzl, Van DH Thiel, Van DH Thiel   +24 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Nutlin-3 promotes HBV replication by activating mTOR-mediated autophagy

Acta Virologica
BackgroundCurrently, there are approximately 240 million individuals worldwide suffering from chronic hepatitis B infection, yet a definitive cure remains elusive.
Shaowei Han, Yuanyuan Li, Junnan Wang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang   +6 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source