Results 61 to 70 of about 618,743 (313)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Hepatoprotective effects of silymarin in management of liver injury caused by tuberculosis treatment

, 2023
Tuberculosis (TB) is a chronic infection of global-health concern because of its high incidence, costly medical treatment, drug resistance and risk of co-infections. Anti-TB treatment involves a combination of drugs with high degree of liver toxicity,
Yeong Yeh Lee, Vincent Tee
core   +1 more source

Hydrogel Loaded with Extracellular Vesicles: An Emerging Strategy for Wound Healing

Pharmaceuticals
An increasing number of novel biomaterials have been applied in wound healing therapy. Creating beneficial environments and containing various bioactive molecules, hydrogel- and extracellular vesicle (EV)-based therapies have respectively emerged as ...
Yucan Yang, Huizhi Chen, Yunjie Li, Junting Liang, Feng Huang, Liyan Wang, Huilai Miao, Himansu Sekhar Nanda, Jin Wu, Xinsheng Peng, Yubin Zhou   +10 more
doaj   +1 more source

Management of Traumatic Liver Injury in a Tertiary Care Hospital in Nepal

Journal of Nepal Health Research Council, 2020
Background: The liver is most frequently injured solid organ in abdominal trauma. The non-operative management is the standard treatment for hemodynamically stable patients.
Harish Chandra Neupane, Kishor Kumar Tamrakar, Abhishek Bhattrai, Tseten Yonjen Tamang, Bishnu Bista, Rajib Chaulagain   +5 more
doaj   +1 more source

Determinants of health-related quality of life in patients with celiac disease: a structural equation modeling

Health and Quality of Life Outcomes, 2021
Background We aimed to investigate the determinants of Health-related quality of life (HRQOL) in Iranian patients with celiac disease (CD) using the structural equation modeling (SEM).
Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Mahdieh Abbasalizad Farhangi, Masood Shirmohammadi, Leila Nikniaz   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania. [PDF]

, 2012
To investigate the timing, incidence, clinical presentation, pharmacokinetics and pharmacogenetic predictors for antiretroviral and anti-tuberculosis drug induced liver injury (DILI) in HIV patients with or without TB co-infection.
Ngaimisi, E., Klaus-Dieter Riedel, Janabi Mohamed, Bakari, Muhammad, Burhenne Juergen, Minzi, Omary, Eric Sandstrom, Mugusi Sabina, Sandstrom Eric, Mohamed Janabi, Omary Minzi, Mugusi Ferdinand, Bakari Muhammad, Burhenne, J., Eleni Aklillu, Muhammad Bakari, Lars Lindquist, Eliford Ngaimisi, Minzi Omary, Riedel Klaus-Dieter, Mugusi, Sabina, Riedel, Klaus-Dieter, Mugusi, F., Sandstrom, E., Juergen Burhenne, Aklillu, E., Riedel, K.D., Ngaimisi Eliford, Lindquist, Lars, Ferdinand Mugusi, Mugusi, Ferdinand, Burhenne, Juergen, Lindquist, L., Lindquist Lars, Mugusi, S., Janabi, Mohamed, Aklillu, Eleni, Aklillu Eleni, Sandstrom, Eric, Sabina Mugusi, Janabi, M., Minzi, O., Bakari, M., Ngaimisi, Eliford   +43 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury

, 2011
Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion ...
Birk, Philipp, Morote-Garcia, Julio C., Rosenberger, Peter, Peter Rosenberger, Eldh, Therese, Andreas Straub, Klemens König, Philipp Birk, Therese Eldh, König, Klemens, Julio C Morote-Garcia, Straub, Andreas, Köhler, David, David Köhler   +13 more
core   +1 more source

Hepatocellular carcinoma: pathogenesis, molecular mechanisms, and treatment advances

Frontiers in Oncology
Hepatocellular Carcinoma (HCC), a highly prevalent malignancy, poses a significant global health challenge. Its pathogenesis is intricate and multifactorial, involving a complex interplay of environmental and genetic factors.
Zhixian Ding, Zhixian Ding, Lusheng Wang, Lusheng Wang, Jiting Sun, Jiting Sun, Lijie Zheng, Lijie Zheng, Yu Tang, Yu Tang, Heng Tang, Heng Tang   +11 more
doaj   +1 more source