Results 131 to 140 of about 4,185,241 (381)

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Science Translational Medicine, 2018
Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration. Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may fail in a ...
T. Bird, M. Müller, L. Boulter, D. Vincent, R. Ridgway, Elena Lopez-Guadamillas, Wei-Yu Lu, T. Jamieson, O. Govaere, A. Campbell, Sofía Ferreira-González, A. Cole, T. Hay, K. Simpson, W. Clark, A. Hedley, Mairi Clarke, Pauline Gentaz, C. Nixon, Steven Bryce, Christos Kiourtis, Joep Sprangers, R. Nibbs, N. Van Rooijen, L. Bartholin, Steven R. McGreal, U. Apte, S. Barry, J. Iredale, A. Clarke, M. Serrano, T. Roskams, O. Sansom, S. Forbes   +33 more
semanticscholar   +1 more source

Hepatic fibrogenesis requires sympathetic neurotransmitters [PDF]

, 2004
Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear.
Diehl, AM, Huang, J, Li, Z, Lin, H, Moran, TH, Oben, JA, Roskams, T, Sinelli, N, Smedh, U, Thomas, SA, Torbenson, M, Yang, S   +11 more
core   +2 more sources

Drug-Induced Liver Injury [PDF]

Clinical Infectious Diseases, 2004
Drug-induced hepatotoxicity is a frequent cause of liver injury. The predominant clinical presentation is acute hepatitis and/or cholestasis, although almost any clinical pathological pattern of acute or chronic liver disease can occur. The pathogenesis of drug-induced liver disease usually involves the participation of the parent drug or metabolites ...
openaire   +3 more sources

Recommendations for the Use of Disease‐Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review

Arthritis Care &Research, EarlyView.
Objective Autoimmune rheumatic diseases commonly affect individuals of childbearing age, with historically increased adverse pregnancy outcomes in this group. The advent of disease‐modifying antirheumatic drugs (DMARDs) has fostered more suitable conditions for pregnancy; however, this is accompanied by challenges in ensuring safe use in reproductive ...
Athena Chin, Alice Terrett, Mihye Kwon, Samuel Whittle, Catherine Hill   +4 more
wiley   +1 more source

Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Hepatology, 2019
Liver regeneration after injury is normally mediated by proliferation of hepatocytes, although recent studies have suggested biliary epithelial cells (BECs) can differentiate into hepatocytes during severe liver injury when hepatocyte proliferation is ...
Jacquelyn O. Russell, Wei-Yu Lu, H. Okabe, M. Abrams, M. Oertel, Minakshi Poddar, Sucha Singh, S. Forbes, S. Monga   +8 more
semanticscholar   +1 more source

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. [PDF]

, 2014
Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are ...
Aroonsakool, Nakon, Brenner, David A, De Minicis, Samuele, Dunkel, Ying, Ghosh, Pradipta, Ho, Samuel B, Lopez-Sanchez, Inmaculada, Mittal, Yash, Muranyi, Andrea, Murray, Fiona, Roh, Yoon-Seok, Seki, Ekihiro, Shanmugam, Kandavel, Singh, Shalini   +13 more
core   +1 more source

Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (Optimizing Primary Care Management of Knee Osteoarthritis [PARTNER]), at 12 months (ACTRN: 12617001595303).
Abdolhay Farivar, Jocelyn L. Bowden, Kim L. Bennell, Andrew M. Briggs, Stephen J. Bunker, Rana S. Hinman, Thorlene Egerton, Simon D. French, Marie Pirotta, Karen Schuck, Venkatesha Venkatesha, Nicholas A. Zwar, David J. Hunter   +12 more
wiley   +1 more source

Manipulation of nitric oxide in an animal model of acute liver injury: The impact on liver and intestinal function [PDF]

Libyan Journal of Medicine, 2007
Background: Nitric oxide may have a protective effect on the liver during endotoxemia and chronic inflammation. There is evidence that it maintains liver and intestinal tissue integrity during inflammatory processes.
Göran Molin, Behzad Kasravi, Diya Adawi
doaj  

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells.
Wenqiang Jiang, Youwen Tan, Mengjie Cai, Ting Zhao, Fei Mao, Xu Zhang, Wenrong Xu, Zhixin Yan, Hui Qian, Yongmin Yan   +9 more
semanticscholar   +1 more source

Rapid growth of an intact human liver transplanted into a recipient larger than the donor [PDF]

, 1987
Two individuals undergoing orthotopic hepatic transplantation received livers from donors who were on average 10 kg smaller than themselves based on recipient ideal body weight.
Diven, W, Francavilla, A, Gavaler, JS, Kam, I, Penkrot, RJ, Polimeno, L, Schade, RR, Smith, J, Starzl, TE, Van Thiel, DH   +9 more
core   +1 more source