Results 171 to 180 of about 4,187,942 (381)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease

open access: yesCells, 2019
Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease. However, most available animal models fail to reflect the whole spectrum of the disease.
Raquel Maeso-Díaz   +6 more
doaj   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

open access: yesAdvanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang   +6 more
wiley   +1 more source

Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

open access: yesPLoS ONE, 2015
Background & aimsAcute liver injury is a clinically important pathology and results in the release of Danger Associated Molecular Patterns, which initiate an immune response.
James A Richards   +10 more
doaj   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

open access: yesAdvanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu   +12 more
wiley   +1 more source

Liver injury. [PDF]

open access: yesBMJ, 1972
H, Bharucha, L R, Marwah, J G, Paul
openaire   +2 more sources

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

open access: yesAdvanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran   +5 more
wiley   +1 more source

Lipoxin-A4 in the rabbit model of atherosclerosis and liver steatosis [PDF]

open access: yes, 2019
BACKGROUND: Obesity is a global health problem that is associated with wide range of diseases, including atherosclerosis and Nonalcoholic fatty liver (NAFL) disease.
Singh, Jaskamal Kaur
core  

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