Results 281 to 290 of about 311,004 (351)

A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases. [PDF]

J Exp Clin Cancer Res
Justo M, Lim Y, Yang H, Floris A, Chandla S, Dagar M, Gangi A, Posadas E, Edderkaoui M, Pandol S, Bhowmick N, Tomasi ML, Lu SC.   +12 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Refining Outcomes in Technically Resectable Colorectal Liver Metastases: A Simplified Risk Model and the Role of Preoperative Chemotherapy. [PDF]

Cancers (Basel)
Kanesada K, Nakajima M, Ioka T, Tomochika S, Shindo Y, Tokumitsu Y, Matsui H, Tanaka H, Nakagami Y, Tsunedomi R, Iida M, Takahashi H, Nagano H.   +12 more
europepmc   +1 more source

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

Advanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang, Ming Wang, Min Liu, Yi‐Jing Chen, Li‐Li Xu, Jin‐Ping Zhou, Fu‐Bing Wang, Shi‐Bo Cheng, Min Xie, Wei‐Hua Huang   +9 more
wiley   +1 more source

Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases. [PDF]

Nat Commun
Alvarez-Villanueva D, Maqueda M, Harti D, Canton E, Andrades E, Bertran J, Martínez-Iniesta M, Solé L, García-Hernández V, Montoto Á, Lobo-Jarne T, Alonso-Marañón J, Herrero-Molinero P, Larrubia-Loring M, Tramuns A, Wynne K, Bera I, Matallanas D, Villanueva A, Bigas A, Iglesias M, Espinosa L.   +21 more
europepmc   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Harnessing early postoperative MRD and VAF dynamics for precision prognosis in resected colorectal liver metastases. [PDF]

J Cancer Res Clin Oncol
Li P, Li T, Huang M, Liu Y, Liu P, Wu Y, Li X, He R, Gan Y, Hong Y, Wang P, Lin J, Huang M.   +12 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

High-intensity focused ultrasound in the multimodal treatment of colorectal cancer liver metastases: A case report. [PDF]

Oncol Lett
Yang Y, Zhang H, Shen Y, Yang F, Zhao D, Lin Y, Huang G.   +6 more
europepmc   +1 more source