Results 121 to 130 of about 591,388 (358)

Causes of adult deaths in developing countries : a review of data and methods [PDF]

open access: yes
Relatively little attention has been paid to the problem of premature adult mortality in developing countries, despite high levels of mortality in many countries - and despite the potentially severe social and economic consequences of adult deaths ...
Hayes, Richard   +3 more
core  

Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]

open access: yes, 2016
Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca   +7 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

De Novo Internal Neoplasms after Liver Transplantation: Increased Risk and Aggressive Behavior in Recent Years? [PDF]

open access: hybrid, 2004
Salvador Benlloch   +8 more
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

open access: yesMolecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker   +3 more
wiley   +1 more source

Hepatojejunostomia periférica: uma alternativa técnica no tratamento paliativo das neoplasias malignas do hilo hepático

open access: yesRevista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Relatar a experiência do nosso Serviço com a descompressão cirúrgica da árvore biliar através de uma hepatojejunostomia periférica. MÉTODO: Entre julho de 2000 a julho de 2005, 11 pacientes foram à laparotomia para ressecção de tumores do hilo ...
Roberto Pelegrini Coral   +4 more
doaj   +1 more source

Large-scale analysis of disease pathways in the human interactome

open access: yes, 2017
Discovering disease pathways, which can be defined as sets of proteins associated with a given disease, is an important problem that has the potential to provide clinically actionable insights for disease diagnosis, prognosis, and treatment ...
Agrawal, Monica   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Leiomioma hepático em paciente imunocompetente

open access: yesRevista do Colégio Brasileiro de Cirurgiões
Diagnosis and treatment of hepatic tumors are a challenge for the surgeon in some situations. There are many histologic types of these neoplasms, and their diagnoses are increasing.
Antonio Nocchi Kalil   +3 more
doaj   +1 more source

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