Results 41 to 50 of about 599,920 (359)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature [PDF]

, 2017
Background: Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas.
Blandamura, Stella, Da Dalt, Gianfranco, Merigliano, Stefano, Pozza, Gioia, Serafini, Simone, Sperti, Cosimo, Valmasoni, Michele   +6 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Metabolic Factors Associated with Endoscopic Atrophy, Intestinal Metaplasia, and Gastric Neoplasms in Helicobacter pylori-Positive Patients

Clinics and Practice
Background: Previous studies demonstrate an association between metabolic factors and Helicobacter pylori-related gastric cancer. However, the association of gastric atrophy or intestinal metaplasia (IM) with these factors remains unknown.
Junya Arai, Hiroaki Fujiwara, Tomonori Aoki, Ryota Niikura, Sozaburo Ihara, Nobumi Suzuki, Yoku Hayakawa, Masato Kasuga, Mitsuhiro Fujishiro   +8 more
doaj   +1 more source

Hepatopulmonary Fistula in a Colorectal Cancer Patient

Case Reports in Hepatology, 2019
Cancer patients with liver metastasis may be candidates for liver surgery and local interventional techniques as part of their treatment. Although rare in this setting, hepatopulmonary fistula has been described as a possible complication.
Maria João Silva, Nuno Almeida Costa, Susana Dias, Maria José Sousa, Maria Fragoso   +4 more
doaj   +1 more source

FEATURES ARTERIAL ANATOMY OF THE LIVER AND ENDOVASCULAR CHEMOEMBOLIZATION OF THE HEPATIC ARTERY IN THE TREATMENT OF PRIMARY AND METASTATIC LIVER CANCERS

Креативная хирургия и онкология, 2017
This article presents an overview and results  of treatment of malignant neoplasms of the  liver hepatic artery  chemoembolization methods in 141 patients. The analysis  of  the results of this method of treatment.
V. V. Plechev, Sh. Kh. Gantsev, F. F. Mufazalov, V. Sh. Ishmetov, M. O. Loginov, R. A. Abdrakhmanov   +5 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Impact of variations in fatty liver on sonographic detection of focal hepatic lesions originally identified by CT [PDF]

Ultrasonography, 2016
Purpose: The aim of this study was to investigate the influence of variations in fatty liver on the ultrasonographic detection of focal liver lesions. Methods: A total of 229 patients with varying degrees of fatty liver and focal liver lesions and 200 ...
Size Wu, Rong Tu, Ruixia Nan, Guangqing Liu, Xiaojing Cui, Xian Liang   +5 more
doaj   +1 more source

Malignant hepatic vascular neoplasm with novel RAF1 and GNA11 mutations: Risk stratification considerations for hepatic small vessel neoplasm (HSVN)

Human Pathology Reports, 2022
GNAQ, GNA11, and GNA14 are paralogues in the GNAQ family that are mutually exclusively mutated in a group of vascular neoplasms with thin-walled capillary-like vasoformative growth, which occur at multiple sites.
Naoki Akanuma, Nancy M. Joseph, Matthew Stachler, Spencer Behr, Toshiyuki Takahashi, Ryan M. Gill   +5 more
doaj   +1 more source