Results 81 to 90 of about 19,245 (266)
Biology DirectBackground The health burden of end-stage liver disease continues to grow, and orthotopic liver transplantation remains the only curative treatment. Three-dimensional (3D) culture systems support the in vitro culture of primary liver cells, allowing them
Sang Luo +6 more
doaj +1 more source
Journal of Bio-X ResearchHepatocellular carcinoma, the most prevalent primary liver malignancy, remains a global health burden characterized by late-stage diagnosis, high recurrence rates, and limited systemic therapeutic options.
Ramaiyan Velmurugan +2 more
doaj +1 more source
Applications of liver organoids [PDF]
SCIENTIA SINICA Vitae, 2022 Chun LI +3 more
openaire +1 more source
3D Hepatic Organoid-Based Advancements in LIVER Tissue Engineering
, 2021 Liver-associated diseases and tissue engineering approaches based on in vitro culture of functional Primary human hepatocytes (PHH) had been restricted by the rapid de-differentiation in 2D culture conditions which restricted their usability.
Amit Panwar, Lay Poh Tan, Prativa Das
core +1 more source
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Guidelines for Manufacturing and Application of Organoids: Liver
International Journal of Stem CellsRecent amendments to regulatory frameworks have placed a greater emphasis on the utilization of in vitro testing platforms for preclinical drug evaluations and toxicity assessments. This requires advanced tissue models capable of accurately replicating liver functions for drug efficacy and toxicity predictions.
Hye-Ran Moon +9 more
openaire +2 more sources
Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies [PDF]
, 2018 Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the second most frequent cause of cancer-related mortality worldwide. The multikinase inhibitor sorafenib is the only treatment option for advanced HCC. Due to tumor heterogeneity,
Ng, Charlotte K.Y. +13 more
core +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang +17 more
wiley +1 more source
Paracrine signals regulate human liver organoid maturation from iPSC
, 2017 A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation. To
Akihiro Asai +11 more
core +1 more source