Results 101 to 110 of about 19,245 (266)

Towards automatization of organoid analysis:A deep learning approach to localize and quantify organoid images

, 2023
The interest in the use of organoids in the biomedical field has increased exponentially in the past years. Organoids, or three-dimensional “mini-organs”, have the ability to proliferate and self-organize in-vitro, while displaying varying morphologies ...
Schomaker, Lambert, Haja, Asmaa, Schomaker, Lambert; id_orcid, Barbara M. Bakker, Haja, Asmaa; id_orcid, Bakker, Barbara M.; id_orcid, Lambert Schomaker, Bakker, Barbara M., Asmaa Haja, José M. Horcas-Nieto, Horcas-Nieto, José M.   +10 more
core   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

The IL-6/JAK/STAT3 Axis in Cholangiocarcinoma and Primary Sclerosing Cholangitis: Unlocking Therapeutic Strategies Through Patient-Derived Organoids

Biomedicines
Background/Objectives: Primary sclerosing cholangitis (PSC) is a rare, incurable liver disease characterized by chronic biliary inflammation and fibrosis. PSC is a significant risk factor for biliary tract cancer (BTC).
Corinna Boden, Laura K. Esser, Leona Dold, Bettina Langhans, Taotao Zhou, Dominik J. Kaczmarek, Maria A. Gonzalez-Carmona, Tobias J. Weismüller, Glen Kristiansen, Jörg C. Kalff, Michael Hölzel, Hanno Matthaei, Marieta I. Toma, Vittorio Branchi   +13 more
doaj   +1 more source

Patient-derived organoid models help define personalized management of gastrointestinal cancer [PDF]

, 2018
BACKGROUND: The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies ...
R A Burkhart, Tiriac, H., Tuveson, D. A., Tiriac, H., M R Aberle, Dejong, C. H. C., Olde Damink, S. W. M., Aberle, M. R., Damink, S. W. M. Olde, Dejong, C. H. C., Damink, S. W. M. Olde; id_orcid, Burkhart, R. A., D A Tuveson, Olde Damink, Steven W. M., H Tiriac, Burkhart, R. A., C H C Dejong, Aberle, M. R., Tuveson, D. A., van Dam, R. M., S W M Olde Damink, Dejong, Cornelis H. C., van Dam, R. M., R M van Dam   +23 more
core   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

, 2017
Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells ...
Lieshout, R. (Ruby), Luc JW van der Laan, van der Laan, Luc; id_orcid, Gavarro, LM, Laura Broutier, Wigmore, S.J. (Stephen J.), Dietmann, Sabine, Bon-Kyoung Koo, Verstegen, M.M.A. (Monique), Mathew J Garnett, Saeb-Parsy, K, Praseedom, RK, Gavarró, L.M. (Lena Morrill), Saeb-Parsy, K. (Kourosh), Monique MA Verstegen, Wigmore, SJ, Laan, L.J.W. (Luc) van der, Gavarró, Lena Morrill, Praseedom, R.K. (Raaj K.), George E Allen, Davies, S.E. (Susan E.), Charles R Bradshaw, Gaspersz, M.P. (Marcia), Broutier, L, Allen, George, Garnett, M.J. (Mathew J.), Lena Morrill Gavarró, Praseedom, Raaj, Koo, BK, Dietmann, S. (Sabine), Huch, Meritxell, Sidorova, O, Huch, M. (Meritxell), Koo, Bon-Kyoung, Lieshout, Ruby, Arnes-Benito, Robert, Raaj K Praseedom, Olga Sidorova, Mastrogiovanni, Gianmarco, Kourosh Saeb-Parsy, Gaspersz, Marcia P, Allen, GE, Dietmann, S, Stephen J Wigmore, Dietman, Sabine, Koo, B.-K. (Bon-Kyoung), Verstegen, Monique; id_orcid, Bradshaw, CR, Francies, Hayley, Huch, M, Arnes, Robert, Georgakopoulos, Nikitas, Georgakopoulos, N, Verstegen, Monique Ma, Nikitas Georgakopoulos, Davies, Susan E, Garnett, Mathew J, Bradshaw, Charles, Wigmore, Stephen, Susan E Davies, van der Laan, Luc Jw, Gaspersz, Marcia, IJzermans, J.N.M. (Jan), Allen, G.E. (George E.), Sidorova, O. (Olga), Broutier, Laura, Mastrogiovanni, G, Bradshaw, C.R. (Charles R.), Saeb-Parsy, Kourosh, Hayley E Francies, Sidorova, Olga, Arnes-Benito, R, Arnes-Benito, R. (Robert), Georgakopoulos, N. (Nikitas), Jan N M IJzermans, Davies, SE, Davies, Susan, Verstegen, Monique, Francies, H.E. (Hayley E.), Broutier, L. (Laura), IJzermans, J.N.M., Meritxell Huch, IJzermans, Jan, van der Laan, Luc, Francies, HE, Mastrogiovanni, G. (Gianmarco), Gianmarco Mastrogiovanni, Sabine Dietmann, Ruby Lieshout, Robert Arnes-Benito, Wigmore, Stephen J., Garnett, MJ, Marcia P Gaspersz, Garnett, Mathew   +93 more
core   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Organoids to model liver disease.

, 2021
The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods.
Nuciforo S, Heim MH
openaire   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

A human liver organoid platform for hepatotoxicity assessment: evaluation using reference compounds

Frontiers in Toxicology
BackgroundRecent advances in organoid technology have enabled the development of human-relevant models. However, their application in toxicity assessments remains limited.
Min Jeong Kim, Seo Yoon Choi, Su Min Youn, Tae Sung Kim, Il Ung Oh, Sang Aeh Park, Jae Ho Oh, Myung Jin Son, Myung Jin Son, Jin Hee Lee   +9 more
doaj   +1 more source