Results 21 to 30 of about 73,874 (216)

Feasibility of measuring spleen stiffness with MR elastography and splenic volume to predict hepatic fibrosis stage.

PLoS ONE, 2019
AimThe aim of this study was to investigate the relationship between spleen stiffness value, splenic volume and the liver fibrosis stages.Materials and methodsThis retrospective study was approved by the institutional review board of our institute.
Yi-Wen Cheng, Ya-Chien Chang, Yao-Li Chen, Ran-Chou Chen, Chen-Te Chou   +4 more
doaj   +1 more source

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

Journal of Hematology & Oncology, 2019
Background Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes.
Yinying Dong, Qiongdan Zheng, Zhiming Wang, Xiahui Lin, Yang You, Sifan Wu, Yaohui Wang, Chao Hu, Xiaoying Xie, Jie Chen, Dongmei Gao, Yan Zhao, Weizhong Wu, Yinkun Liu, Zhenggang Ren, Rongxin Chen, Jiefeng Cui   +16 more
doaj   +1 more source

Liver stiffness by transient elastography predicts liver-related complications and mortality in patients with chronic liver disease. [PDF]

PLoS ONE, 2014
Liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) is a validated method for noninvasively staging liver fibrosis. Most hepatic complications occur in patients with advanced fibrosis. Our objective was to determine the ability of
Jack X Q Pang, Scott Zimmer, Sophia Niu, Pam Crotty, Jenna Tracey, Faruq Pradhan, Abdel Aziz M Shaheen, Carla S Coffin, Steven J Heitman, Gilaad G Kaplan, Mark G Swain, Robert P Myers   +11 more
doaj   +1 more source

Transient Elastography in Community Alcohol Services: Can It Detect Significant Liver Disease and Impact Drinking Behaviour?

Biomedicines, 2022
Introduction: Alcohol is the leading cause of cirrhosis in Western populations. The early identification of high-risk drinkers followed by intervention is an effective way to reduce harm.
Mohsan Subhani, David J. Harman, Robert A. Scott, Lucy Bennett, Emilie A. Wilkes, Martin W. James, Guruprasad P. Aithal, Stephen D. Ryder, Indra Neil Guha   +8 more
doaj   +1 more source

Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

PLoS ONE, 2013
BackgroundFor patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population.AimsTo establish the normal ranges of liver
James Fung, Cheuk-kwong Lee, Monica Chan, Wai-kay Seto, Danny Ka-ho Wong, Ching-lung Lai, Man-fung Yuen   +6 more
doaj   +1 more source

Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study

Heliyon, 2020
Cirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS.
Edford Sinkala, Michael Vinikoor, Alice Miyanda Siyunda, Kanekwa Zyambo, Ellen Besa, Bright Nsokolo, Gilles Wandeler, Graham R. Foster, Paul Kelly   +8 more
doaj   +1 more source

Assessment of pathologic increase in liver stiffness enables earlier diagnosis of CFLD: Results from a prospective longitudinal cohort study. [PDF]

PLoS ONE, 2017
About 30% of patients with Cystic Fibrosis (CF) develop CF-associated liver disease (CFLD). Recent studies have shown that transient elastography (TE), as a method to quantify liver stiffness, allows non-invasive diagnosis of CFLD in adults and children ...
Victoria Klotter, Caroline Gunchick, Enno Siemers, Timo Rath, Helge Hudel, Lutz Naehrlich, Martin Roderfeld, Elke Roeb   +7 more
doaj   +1 more source

Liver Stiffness by Transient Elastography Correlates With Degree of Portal Hypertension in Common Variable Immunodeficiency Patients With Nodular Regenerative Hyperplasia

Frontiers in Immunology, 2022
Nodular regenerative hyperplasia (NRH) is associated with high morbidity and mortality in patients with common variable immunodeficiency (CVID). While liver biopsy is the gold standard for NRH diagnosis, a non-invasive technique could facilitate early ...
Daniel V. DiGiacomo, Jessica E. Shay, Rory Crotty, Nancy Yang, Patricia Bloom, Kathleen Corey, Sara Barmettler, Jocelyn R. Farmer   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Spleen Stiffness Measurement as a Predictor of Advanced Liver Fibrosis in Chronic Hepatitis B Patients

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Background: Chronic hepatitis B is a viral infection that may progress to liver fibrosis. Progressive fibrosis increases portal pressure, leading to elevated spleen stiffness.
Carisa Irene Hertanto, Ummi Maimunah, Aryati -, Muhammad Miftahussurur   +3 more
doaj   +1 more source