Results 81 to 90 of about 3,082,572 (406)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Management of patients at the hepatopancreatobiliary unit of a London teaching hospital during the COVID-19 pandemic

Scientific Reports, 2023
To mitigate COVID-19-related shortage of treatment capacity, the hepatopancreatobiliary (HPB) unit of the Royal Free Hospital London (RFHL) transferred its practice to independent hospitals in Central London through the North Central London Cancer ...
Sebastian M. Staubli, Dimitri A. Raptis, Shahi Ghani, Brian R. Davidson, Giuseppe K. Fusai, Charles Imber, Sateesh Iype, David Nasralla, Theodora Pissanou, Sakhawat Rahman, Dinesh Sharma, Pascale Tinguely, Fares Haddad, Miranda Dodd, Chris Dann, David Walker, Joerg-Matthias Pollok, On behalf of the Royal Free Hospital London HPB team   +17 more
doaj   +1 more source

Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]

, 1994
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold, Billingham, Billingham, Billingham, Calne, Calne, Cohen, Corry, Coutinho, Dahmen, Davies, Demetris, Demetris, Garnier, Goulmy, Hoffmann, Houssaint, Jerne, Kamada, Liegeois, Liegeois, Mayumi, Monaco, Monaco, Murase, Ono, Peacock, Perelson, Qian, Rao, Russell, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Strelein, Thomas, Wood, Zimmerman   +45 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Living Related Donor Liver Transplantation with Atrio- Caval Anastomosis of Inferior Vena Cava Graft Stored in Deep-Freeze for Budd-Chiari Syndrome

International Journal of Organ Transplantation Medicine, 2015
We have previously reported our experience in inferior vena cava resection and reconstruction techniques during liver transplantation for Budd-Chiari syndrome.
F Yaylak, V Ince, B Barut, B Unal, M Kilic, S Yilmaz   +5 more
doaj  

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization

BMC Cancer, 2018
Background There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC).
Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang, Ming-qing Xu   +8 more
doaj   +1 more source

The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline

Transplantation, 2016
Living donor liver transplantation (LDLT) has been increasingly embraced around the world as an important strategy to address the shortage of deceased donor livers.
Charles M. Miller, C. Quintini, A. Dhawan, F. Durand, J. Heimbach, H. L. Kim-Schluger, Eirini Kyrana, Sung‐Gyu Lee, J. Lerut, C. Lo, Elizabeth A. Pomfret   +10 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Retained Foreign Body in Transplanted Liver

International Journal of Organ Transplantation Medicine, 2015
Liver transplantation is a technically complex and long surgical procedure. A large quantity of various materials such as catheters, sutures, needles and clips are frequently used during the procedure.
C Kayaalp, S K?rm?z?, R Kutlu, MA Yagci, B Isik, S Yilmaz   +5 more
doaj