Results 71 to 80 of about 427,437 (355)

Short- and Long-term Outcomes between Young and Older HCC Patients Exceeding The Milan Criteria after Hepatectomy

Annals of Hepatology, 2018
Aim. The objective of this study was to evaluate short- and long-term survival after surgical treatment between young and older hepatocellular carcinoma (HCC) patients beyond the Milan criteria.Material and methods. One hundred fifty-seven HCC patients (≤
Junyi Shen, Chuan Li, Lvnan Yan, Bo Li, Mingqing Xu, Jiayin Yang, Wentao Wang, Tianfu Wen   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization

BMC Cancer, 2018
Background There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC).
Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang, Ming-qing Xu   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Liver transplantation for Wilson's disease: The burden of neurological and psychiatric disorders

, 2005
A retrospective data analysis on liver transplantation for Wilson's disease (WD) was performed among Italian Liver Transplant Centers. Thirty-seven cases were identified. The main indication for liver transplantation was chronic advanced liver disease in
Andriulli, A, Grazi G. L., S.t.u.r.n.i.o.l.o. GC, Aresu G., Castagneto M., FASSATI L. R, Slim A. O. , Strazzabosco M, Mirante, VG, Trevisan, CP, MIRANTE V. G, FAGIUOLI S., Rapaccini G. L., Rondinara, GF, CILLO, UMBERTO, Filla A., Del Gaudio, M, Salizzoni, M, MEDICI, VALENTINA, Valente U. , Zanus G., Burra P., Forti, D, Medici, V, Angelico, M, TREVISAN, CARLO PIETRO, ANGELICO, MARIO, Melada E., Sturniolo. GC, Caccamo L., Tisone, G, Pompili, Maurizio, Fagiuoli, S, Marzano A., Valente U., Zanus G., TISONE, GIUSEPPE, DEL GAUDIO M, Cillo, U, Nardo B., D'Amico D. F., POMPILI M, Aresu G., Burra P., Caccamo L., Castagneto M., D'Amico D.F., Dardano G., Filla A., Gasbarrini A., Gasbarrini G., Gianni S., Grazi G.L., Martines D., Marzano A., Melada E., Nardo B., Pevere S., Rapaccini G.L., Rizzetto M., Rondinara, GF, Gasbarrini G., Pevere S., Gasbarrini A., Martines D., Rizzetto M., FORTI D, Slim A.O., Strazzabosco M, Gianni S., Dardano G., STURNIOLO, GIACOMO, Fassati, LR, Pompili, M   +51 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Long-Term Outcome Following Liver Transplantation for Primary Hepatic Tumors—A Single Centre Observational Study over 40 Years

, 2023
The incidence of pediatric liver tumors in general has been rising over the last years and so is the number of children undergoing liver transplantation for this indication.
Mutschler, Frauke E., Junge, Norman; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Mutschler, Frauke E.; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Vondran, Florian W. R.; 3Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany, Baumann, Ulrich; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Pfister, Eva-Doreen, Pfister, Eva-Doreen; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Laue, Tobias; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Ohlendorf, Johanna, Richter, Nicolas; 3Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany, Ohlendorf, Johanna; 2Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, 30625 Hannover, Germany, Leiskau, Christoph; 1Pediatric Gastroenterology, Department of Pediatrics and Adolescent Medicine, University Medical Centre Göttingen, Georg August University Goettingen, 37075 Goettingen, Germany, Junge, Norman, Vondran, Florian W. R., Richter, Nicolas, Leiskau, Christoph, Laue, Tobias, Baumann, Ulrich   +17 more
core   +1 more source