Results 161 to 170 of about 4,165,678 (306)

Individual Alcohol Consumption Depending on Regional Living Conditions: Results of a Russian Nationwide Study Based on 2012-2022 Data. [PDF]

J Res Health Sci
Maksimov SA, Shalnova SA, Balanova YA, Imaeva AE, Kotova MB, Kashtanova DA, Kontsevaya AV, Drapkina OM.   +7 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Epidemiologia do distress psicológico: estudo transversal de base populacional

Revista de Saúde Pública
OBJETIVO: Determinar a prevalência e a distribuição de distress na esfera psicológica na população urbana adulta. MÉTODOS: Foram estudadas 3.942 pessoas maiores de 20 anos, do município de Pelotas, RS.
Felipe Sparrenberger, Iná dos Santos, Rosângela da Costa Lima   +2 more
doaj  

Protocol for the HALDI study-conceptual framework for investigating health and living conditions in an arctic area of Sweden with a multiethnic population. [PDF]

Ann Med
Nägga K, Axelsson P, Storm Mienna C.
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Condições de vida e estrutura ocupacional associadas a transtornos mentais comuns

Revista de Saúde Pública
OBJETIVO: Determinar a prevalência de transtornos mentais comuns e analisar sua associação a condições de vida e inserção na estrutura ocupacional. MÉTODOS: Estudo transversal conduzido em 1993, em Olinda, PE, envolvendo 621 adultos de 15 ou mais anos em
Ana Bernarda Ludermir, Djalma A de Melo Filho   +1 more
doaj  

Health status and living conditions of north-bound migrant minors in Mexico at place of origin and during the migration journey: A cross-sectional, mixed-methods study. [PDF]

J Migr Health
Aranda Z, Sedas AC, Bernal D, Pulido-Manzanero J, Regidor E, Mandalakas AM, Fredricks K.   +6 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Diferenciais intra-urbanos no Município de Florianópolis, Santa Catarina, Brasil: potencial de uso para o planejamento em saúde

Cadernos de Saúde Pública
Partindo do pressuposto de que a ocupação espacial da população é um processo socialmente construído, e que o espaço social é determinante no processo saúde/doença, o presente estudo identificou e agrupou os setores homogêneos quanto à condição de vida ...
Josimari Telino de Lacerda, Maria Cristina Marino Calvo, Sérgio Fernando Torres de Freitas   +2 more
doaj  

Older persons' experiences with wearable sensor-based fall risk screening in free-living conditions - a qualitative study. [PDF]

BMC Geriatr
Törnblom M, Rönkkö K, Ådahl K, Karlsson S, Olsson Möller U, Nivestam A.   +5 more
europepmc   +1 more source